106622-48-4

Basic information

• Product Name: dimethyl (1R,4aS,8aS)-5,5,8a-trimethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-1,2-dicarboxylate
• CAS NO: 106622-48-4
• Molecular Formula: C₁₇H₂₆O₄
• Molecular Weight: 294.3859
• Mol File: 106622-48-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 350°C at 760 mmHg
• Flash Point: 163°C
• Density: 1.058g/cm³
• Vapor Pressure: 4.52E-05mmHg at 25°C
• Refractive Index: 1.484
• CAS DataBase Reference: dimethyl (1R,4aS,8aS)-5,5,8a-trimethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl (1R,4aS,8aS)-5,5,8a-trimethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-1,2-dicarboxylate(106622-48-4)
• EPA Substance Registry System: dimethyl (1R,4aS,8aS)-5,5,8a-trimethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-1,2-dicarboxylate(106622-48-4)

Safety Data

• Hazardous Substances Data: 106622-48-4(Hazardous Substances Data)

Upstream product

• 71557-96-5 dimethyl 3,5,6,7,8,8a-hexahydro-5,5,8a-trimethylnaphthalene-1,2-dicarboxylate 
• 79679-67-7 dimethyl (4aRS,5SR)-1,2,3,4,4a,5-hexahydro-1,1,4a-trimethylnaphthalene-5,6-dicarboxylate 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 432-25-7 2,6,6-trimethylcyclohex-1-enecarbaldehyde 
• 5293-90-3 1,3,3-trimethyl-2-vinylcyclohexene 
• 132982-84-4 4,4,8a-trimethyl-Δ⁸-carbomethoxy-trans-octahydronaphthalene 
• 16776-05-9 (+-)-5,5,8a-trimethyl-(4ar,8at)-octahydro-naphthalen-1-one 
• 79679-67-7 dimethyl (4aRS,5RS)-1,2,3,4,4a,5-hexahydro-1,1,4a-trimethylnaphthalene-5,6-dicarboxylate 
• 87570-43-2 1-(2,6,6-Trimethyl-cyclohex-1-enyl)-2-trimethylsilanyl-ethanol 
• 86558-53-4 Dimethoxy-2',2' ethyl-2 trimethyl-1,3,3 cyclohexene-1 
• 41613-59-6 1-ethynyl-2,2,6-trimethyl-1-cyclohexanol 
• 472-66-2 (2,6,6-trimethyl-1-cyclohexen-1-yl)acetaldehyde 
• 361544-76-5 5,5,8a-Trimethyl-1,5,6,7,8,8a-hexahydro-naphthalene-1,2-dicarboxylic acid dimethyl ester 

Downstream Products

• 6754-20-7 Polygodial 
• 2326-89-8 (+/-)-drimenine 
• 33118-34-2 polygodial 
• 5956-39-8 polygodial 
• 80648-22-2 dimethyl 1,4,4a,5,6,7,8,8a-octahydro-1α-hydroxy-5,5,8a-trimethyl-4aα,8aβ-naphthalene-1,2-dicarboxylate 
• 5956-39-8 (1R,4aR,8aS)-5,5,8a-Trimethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalene-1,2-dicarbaldehyde 
• 5956-39-8 (1S,4aR,8aS)-5,5,8a-Trimethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalene-1,2-dicarbaldehyde 
• 2326-89-8 drimenin 
• 67594-76-7 isodrimeninol 
• 67594-76-7 (5aR,9aR,9bS)-6,6,9a-Trimethyl-1,3,5,5a,6,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-1-ol 
• 80648-21-1 9-hydroxy-cinnamolide 

Relevant articles and documents

An alternative route to (±)-warburganal synthon

The transformation of the ketone (1) to the unsaturated diester (11) a potential intermediate for the warburganal (12) is described. The Wittig reaction of theketone (1) with methylenetriphenylphosphorane afforded the olefin (2) which reacts with Woodward

66. Stereoselectivity of Dienamine Cycloadditions. Synthesis of Functionalised Decalins and Drimanes

The cycloaddition stereoselectivity of dienamines 1-4 with dimethyl fumarate and fumaronitrile has been investigated, and functionalised decalins 21-40 have been prepared by elimination of Me2NH from cycloadducts 7-11 and 15-20; in the context of the synthesis of drimane sesquiterpenes, the reduction of dienediesters 29 and 30 is also described.

Synthesis of all possible stereoisomers of polygodial

The three possible isomers of polygodial, epimers at C-9, cis and trans fused, are described.Controlled kinetic and thermodynamic epimerizations allow preparation of all stereoisomers from the same key intermediate.