106647-71-6

Basic information

• Product Name: 26,27-dimethyl-24,24-difluoro-1,25-dihydroxyvitamin D3
• Synonyms: 26,27-dimethyl-24,24-difluoro-1,25-dihydroxyvitamin D3;24F2-1,25(Oh)2(me)2D3;26,27-Dimethyl-24,24-difluoro-1alpha,25-dihydroxyvitamin D3;Dmdfdh-D3
• CAS NO: 106647-71-6
• Molecular Formula: C₂₉H₄₆F₂O₃
• Molecular Weight: 0
• Mol File: 106647-71-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 601.5°C at 760 mmHg
• Flash Point: 317.6°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 5.6E-17mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: 26,27-dimethyl-24,24-difluoro-1,25-dihydroxyvitamin D3(CAS DataBase Reference)
• NIST Chemistry Reference: 26,27-dimethyl-24,24-difluoro-1,25-dihydroxyvitamin D3(106647-71-6)
• EPA Substance Registry System: 26,27-dimethyl-24,24-difluoro-1,25-dihydroxyvitamin D3(106647-71-6)

Safety Data

• Hazardous Substances Data: 106647-71-6(Hazardous Substances Data)

Usage

Chemical compound

26,27-dimethyl-24,24-difluoro-1,25-dihydroxyvitamin D3
Synthetic derivative of vitamin D3
Modified form of calcitriol

Role

Regulates calcium and phosphorus metabolism
Developed for therapeutic use
Intended for conditions like osteoporosis and renal osteodystrophy

Altered structure

Contains methyl and fluoro groups
Enhanced biological activity and metabolic stability
Potential treatment for autoimmune diseases and cancer
Represents an advancement in the development of vitamin D analogs.

InChI:InChI=1/C29H46F2O3/c1-6-28(34,7-2)29(30,31)16-14-19(3)24-12-13-25-21(9-8-15-27(24,25)5)10-11-22-17-23(32)18-26(33)20(22)4/h10-11,19,23-26,32-34H,4,6-9,12-18H2,1-3,5H3/b21-10+,22-11-/t19-,23-,24-,25?,26?,27-/m1/s1

Upstream product

• 69454-96-2 methyl 3β-hydroxy-24-nor-5-cholen-23-oate 
• 1474-14-2 3β-acetoxybisnor-5-cholenic acid 
• 67711-02-8 3β-acetoxy-23,24-dinorchol-5-en-22-oyl chloride 
• 33168-65-9 methyl 3β-acetoxy-24-norchol-5-en-23-oate 
• 123836-08-8 5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolino)-24,24-difluoro-26,27-dimethylcholest-6-ene-3β,25-diol 3-acetate 
• 123836-01-1 ethyl 24,24-difluoro-23-<oxy>-3β-(methoxymethoxy)homochol-5-en-25-oate 
• 174293-44-8 ethyl 24,24-difluoro-23-hydroxy-3β-(methoxymethoxy)homochol-5-en-25-oate 
• 106647-58-9 24,24-difluoro-26,27-dimethylcholest-5-ene-3β,25-diol 3-acetate 
• 123836-12-4 24,24-difluoro-1α,25-dihydroxy-26,27-dimethyl-3,5-cyclovitamin D3 
• 106647-61-4 24,24-Difluoro-25-hydroxy-26,27-dimethylvitamin D₃ 
• 106647-59-0 24,24-difluoro-26,27-dimethylcholesta-5,7-diene-3,25-diol 
• 123836-09-9 (R)-3-{(Z)-2-[(1R,3aR,7aR)-1-((R)-5-Ethyl-4,4-difluoro-5-hydroxy-1-methyl-heptyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-4-methyl-cyclohex-3-enol 
• 123836-06-6 24,24-difluoro-26,27-dimethylcholest-5-ene-3β,25-diol 
• 123835-97-2 methyl 3β-(methoxymethoxy)-24-norchol-5-en-23-oate 

Relevant articles and documents

Synthesis and Biological Activity of Novel Vitamin D Analogues: 24,24-Difluoro-25-hydroxy-26,27-dimethylvitamin D3 and 24,24-Difluoro-1α,25-dihydroxy-26,27-dimethylvitamin D3

We synthesized 24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D3 (16) and 24,24-difluoro-1α,25-dihydroxy-26,27-dimethylvitamin D3 (21), from 3β-hydroxy-22,23-dinorcholenic acid 3-acetate.Compound 16 was found to be a highly potent v