106647-61-4

Basic information

• Product Name: 24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D3
• Synonyms: 24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D3
• CAS NO: 106647-61-4
• Molecular Formula: C₂₉H₄₆F₂O₂
• Molecular Weight: 464.67
• Mol File: 106647-61-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 567.2°Cat760mmHg
• Flash Point: 296.8°C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 3.17E-15mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: 24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D3(CAS DataBase Reference)
• NIST Chemistry Reference: 24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D3(106647-61-4)
• EPA Substance Registry System: 24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D3(106647-61-4)

Safety Data

• Hazardous Substances Data: 106647-61-4(Hazardous Substances Data)

Usage

General Description

24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D3 is a synthetic analog of vitamin D3 that contains an additional fluorine atom and methyl groups at specific positions in the molecule. This chemical has been studied for its potential as a therapeutic agent for the treatment of conditions related to vitamin D deficiency, such as osteoporosis and certain types of cancer. It is believed to have enhanced potency and activity compared to natural vitamin D3, serving as a promising candidate for the development of new pharmaceuticals. However, further research is needed to fully understand its efficacy and safety for human use.

InChI:InChI=1/C29H46F2O2/c1-6-28(33,7-2)29(30,31)18-16-21(4)25-14-15-26-22(9-8-17-27(25,26)5)11-12-23-19-24(32)13-10-20(23)3/h11-12,21,24-26,32-33H,3,6-10,13-19H2,1-2,4-5H3/b22-11+,23-12-/t21-,24+,25-,26?,27-/m1/s1

Upstream product

• 123836-08-8 5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolino)-24,24-difluoro-26,27-dimethylcholest-6-ene-3β,25-diol 3-acetate 
• 174293-44-8 ethyl 24,24-difluoro-23-hydroxy-3β-(methoxymethoxy)homochol-5-en-25-oate 
• 106647-58-9 24,24-difluoro-26,27-dimethylcholest-5-ene-3β,25-diol 3-acetate 
• 106647-59-0 24,24-difluoro-26,27-dimethylcholesta-5,7-diene-3,25-diol 
• 123836-06-6 24,24-difluoro-26,27-dimethylcholest-5-ene-3β,25-diol 
• 111478-66-1 3β-(methoxymethoxy)-24-norchol-5-en-23-al 
• 33168-65-9 methyl 3β-acetoxy-24-norchol-5-en-23-oate 
• 67711-02-8 3β-acetoxy-23,24-dinorchol-5-en-22-oyl chloride 
• 1474-14-2 3β-acetoxybisnor-5-cholenic acid 
• 69454-96-2 methyl 3β-hydroxy-24-nor-5-cholen-23-oate 
• 123836-09-9 (R)-3-{(Z)-2-[(1R,3aR,7aR)-1-((R)-5-Ethyl-4,4-difluoro-5-hydroxy-1-methyl-heptyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-4-methyl-cyclohex-3-enol 
• 123836-01-1 ethyl 24,24-difluoro-23-<oxy>-3β-(methoxymethoxy)homochol-5-en-25-oate 
• 123835-97-2 methyl 3β-(methoxymethoxy)-24-norchol-5-en-23-oate 

Downstream Products

• 123836-14-6 Acetic acid (1R,5S)-3-[2-[(1R,3aS,7aR)-1-((R)-5-ethyl-4,4-difluoro-5-hydroxy-1-methyl-heptyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-5-hydroxy-4-methylene-cyclohexyl ester 
• 123836-13-5 24,24-difluoro-1α,25-dihydroxy-26,27-dimethylvitamin D3 3-acetate 
• 124018-42-4 5,6-trans-24,24-difluoro-1α,25-dihydroxy-26,27-dimethylvitamin D3 
• 106647-71-6 26,27-Dimethyl-24,24-difluoro-1,25-dihydroxyvitamin D₃ 
• 123836-10-2 24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D₃ 3-tosylate 

Relevant articles and documents

Synthesis and Biological Activity of Novel Vitamin D Analogues: 24,24-Difluoro-25-hydroxy-26,27-dimethylvitamin D3 and 24,24-Difluoro-1α,25-dihydroxy-26,27-dimethylvitamin D3

We synthesized 24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D3 (16) and 24,24-difluoro-1α,25-dihydroxy-26,27-dimethylvitamin D3 (21), from 3β-hydroxy-22,23-dinorcholenic acid 3-acetate.Compound 16 was found to be a highly potent v