106691-72-9

Basic information

• Product Name: (R)-tert-butyl 2-oxoazepan-3-ylcarbaMate
• Synonyms: (R)-tert-butyl 2-oxoazepan-3-ylcarbaMate;CarbaMic acid, N-[(3R)-hexahydro-2-oxo-1H-azepin-3-yl]-, 1,1-diMethylethyl ester;tert-Butyl ((3R)-2-oxoazepan-3-yl)carbamate
• CAS NO: 106691-72-9
• Molecular Formula: C₁₁H₂₀N₂O₃
• Molecular Weight: 228
• EINECS: -0
• Mol File: 106691-72-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-tert-butyl 2-oxoazepan-3-ylcarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-butyl 2-oxoazepan-3-ylcarbaMate(106691-72-9)
• EPA Substance Registry System: (R)-tert-butyl 2-oxoazepan-3-ylcarbaMate(106691-72-9)

Safety Data

• Hazardous Substances Data: 106691-72-9(Hazardous Substances Data)

Usage

General Description

(R)-tert-butyl 2-oxoazepan-3-ylcarbaMate is a chemical compound with the molecular formula C12H21NO3. It is a carbaMate derivative that contains a tertiary butyl group and a 2-oxoazepan-3-yl functional group. (R)-tert-butyl 2-oxoazepan-3-ylcarbaMate is often used in organic synthesis and medicinal chemistry research. It has potential applications in the development of new drugs and pharmaceuticals due to its unique chemical properties. Additionally, it has been studied for its potential therapeutic effects in various diseases and conditions. The compound's structure and reactivity make it a valuable tool in the study of reaction mechanisms and drug design.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 28957-33-7 (R)-3-amino-azepan-2-one 
• 7274-88-6 D-lysine hydrochloride 
• 1389338-59-3 C₁₁H₁₈N₂O₃ 
• 170899-08-8 N-(tert-butoxycarbonyl)-D-allylglycine 
• 106719-44-2 Boc-D-Lys-OH 

Downstream Products

• 643045-92-5 [(3S)-hexahydro-1-(2-hydroxy-3-phenoxypropyl)-2-oxo-1H-azepin-3-yl]-carbamic acid 1,1-dimethylethyl ester 
• 1008161-75-8 N-methyl-((R)-azepan-2-one-3-ylamino-(R)-oxo-3-phenylpropan-2-yl)dec-9-enamide 
• 1067658-76-7 N-methyl-((R)-azepan-2-one-3-ylamino-(S)-oxo-3-phenylpropan-2-yl)dec-9-enamide 
• 1067659-02-2 tert-butyl methyl((R)-azepan-2-one-3-ylamino-(R)-oxo-3-phenylpropan-2-yl)carbamate 
• 1067658-96-1 tert-butyl methyl((R)-azepan-2-one-3-ylamino-(S)-oxo-3-phenylpropan-2-yl)carbamate 
• 146349-40-8 methyl 3(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetate 
• 146349-31-7 3(R)-<<<1-(benzyloxycarbonyl)-2(S)-pyrrolidinyl>carbonyl>amino>-2-oxo-1-perhydroazepineacetamide 
• 250682-53-2 1-N-[(benzyloxycarbonyl)methyl]-3(R)-[(tert-butyloxycarbonyl)amino]azepan-2-one 

Relevant articles and documents

Convenient synthesis of (R)-3-[(tert -Butoxycarbonyl)amino]piperidine and (R)-3-[(tert -Butoxycarbonyl)amino]azepane

(R)-3-[(tert -Butoxycarbonyl)amino]piperidine and (R)-3-[(tert -butoxycarbonyl)amino]azepane were prepared in two steps starting from d -ornithine and d -lysine, respectively. In the key step, N -Boc-protected 3-aminolactams were converted into imido esters by O-alkylation and then hydrogenated to amines, under mild conditions (5 bar H 2, room temperature) and without isolation, over a standard hydrogenation catalyst (5% Pt/C).

Resolution of the Confusion in the Assignments of Configuration for the Ciliatamides, Acylated Dipeptides from Marine Sponges

Direct comparison of authentic ciliatamide A with four synthetic isomers (1-4) by means of NMR and chiral-phase HPLC revealed that ciliatamide A possesses the 12R (d-N-MePhe residue) and 22S (l-Lys residue) configurations, which were not identical with either our previous assignment or those proposed by others through total synthesis. The absolute configuration of the methionine sulfoxide residue in ciliatamide D was also revised to be d.

Synthesis and characterization of bradykinin B2 receptor agonists containing constrained dipeptide mimics

We have previously shown that substitution of the D-Tic-Oic dipeptide by a (3S)-[amino]-5-(carbonylmethyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one (D-BT) moiety in the bradykinin B2 receptor antagonist HOE 140 resulted in a full potent and sel