106698-08-2Relevant academic research and scientific papers
Synthesis of 1-aroyl-1,2-dihydro-3H-indol-3-ones via cyclization of N-[2-(2-chloroacetyl)phenyl]benzamides with triethylamine in the presence of DI-tert-butyl dicarbonate
Kobayashi, Kazuhiro,Kado, Daiki,Nishikawa, Kohei
, p. 1063 - 1074 (2016)
1-Aroyl-1,2-dihydro-3H-indol-3-ones can now be conveniently obtained from 2-aryl-4-(Z)-(chloromethylidene)-4H-3,1-benzoxazines using an easy operated three-step sequence under mild conditions. Thus, the starting materials are hydrolyzed with dilute hydroc
Organophosphane-Catalyzed Construction of Functionalized 2-Ylideneoxindoles via Direct β-Acylation
Jeng, Wey-Chyng,Chien, Po-Chung,Vagh, Sandip Sambhaji,Edukondalu, Athukuri,Lin, Wenwei
, p. 4409 - 4418 (2021/08/25)
We report an efficient method for the direct β-acylation of 2-ylideneoxindoles with acyl chlorides that is catalyzed by organophosphanes in the presence of base. A variety of functionalized 2-ylideneoxindoles were prepared in moderate to good yields under
A Novel Synthesis of 1-Acylindoxyls
Chien, Chun-Sheng,Hasegawa, Atsushi,Kawasaki, Tomomi,Sakamoto, Masanori
, p. 1493 - 1496 (2007/10/02)
A novel and efficient synthesis of 1-acylindoxyls (3) from 1-acylindoles (1) is described.The procedure involves the demethoxylation with stannic chloride of 1-acyl-3-hydroxy-2-methoxy-indoline (2), which were obtained by the MoO5 oxidation of 1 in methanol.Since the MoO5 oxidation of 2-substituted 1-acylindoles (1f and 1g) gave not the corresponding indolines (2f and 2g), but 2-hydroxyindoxyls (4f and 4g), 2f and 2g were obtained by the methylation of 4f and 4g with diazomethane to give 5f and 5g, followed by the reduction of 5f and 5g with sodium borohydride, respectively.Keywords - indoxyl; indole; indoline; oxidation; demethoxylation; peroxomolybdenum complex; methylation; diazomethane; reduction; sodium borohydride
