106711-99-3

Upstream product

• 538-51-2 benzylidene phenylamine 
• 703-59-3 homophthalic anhydride 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 

Relevant academic research and scientific papers

Iodine as a mild, efficient, and cost-effective reagent for the synthesis of cis-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acids

Arylimines generated in situ from aromatic aldehydes and anilines undergo smooth coupling with homophthalic anhydride in the presence of 10 mol% of molecular iodine under mild and neutral conditions to afford the corresponding cis-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acids in excellent yields with high cis selectivity. The use of iodine makes this procedure simple, convenient, and cost-effective. Georg Thieme Verlag Stuttgart.

A stereoselective three-component reaction: One-pot synthesis of cis-isoquinolonic acids catalyzed by silica sulfuric acid under mild and heterogeneous conditions

A mild and stereoselective three-component one-step synthesis of cis-isoquinolonic acid using silica sulfuric acid as a heterogeneous catalyst from an aldehyde, amine and homophthalic anhydride in acetonitrile is described. This new method produces pure p

A stereoselective three-component reaction: KAl(SO4) 2·12H2O, an efficient and reusable catalyst for the one-pot synthesis of cis-isoquinolonic acids

(Chemical Equation Presented). KAl(SO4)2· 12H2O is found to catalyze efficiently the stereo-selective one-pot three-component cyclocondensation of homophthalic anhydride, aldehydes, and amines under mild conditions to afford the corresponding cis-isoquinolonic acids in good yields.

One-pot, three-component synthesis of cis-isoquinolonic acids using ZnCl2, AlCl3-SiO2 as catalyst

ZnCl2, AlCl3-SiO2 catalyzes efficiently the three-component condensation reaction of aldehydes, amines, and homophthalic anhydride in dichloromethane to afford the corresponding cis-isoquinolonic acids in good yields at ro

Room temperature ionic liquids promoted three-component coupling reactions: A facile synthesis of cis-isoquinolonic acids

Room temperature ionic liquids are found to catalyze efficiently the three component-coupling reactions of aldehydes, amines and homophthalic anhydride under mild and convenient conditions to afford the corresponding cis-isoquinolonic acids in excellent yields with high cis-selectivity.

KAL(SO4)2·12H2O: An efficient catalyst for the stereoselective synthesis of cis-isoquinolonic acids

KAl(SO4)2·12H2O is found to catalyze efficiently the stereoselective cyclocondensation of homophthlic anhydride with imines under mild conditions to afford the corresponding cis-isoquinolonic acids in good yields.

One-pot synthesis of cis-isoquinolonic acid derivatives via three-component reaction of homophthalic anhydride with aldehydes and amines using ytterbium(III) triflate as catalyst

Ytterbium(III) triflate efficiently catalyzes the one-pot reaction of homophthalic anhydride with aldehydes and amines at ambient temperature to afford the corresponding cis-isoquinolonic acid derivatives in good to excellent yields with high diastereoselectivity. This method provides a novel and much improved modification of the three-component reaction in terms of mild reaction conditions, short reaction times, clean reaction profiles, small quantity of catalyst, and simple work-up procedure. Another important feature of this method is that the catalyst can be easily recovered from the aqueous layer after the reaction and can be reused with no loss of activity.

HIGHLY ACCELERATED REACTIONS IN A MICROWAVE OVEN : SYNTHESIS OF HETEROCYCLES

Efficient synthesis of a wide variety of heterocycles on 0.1 to 200 g scale was conducted in organic solvents in a commercial microwave oven in a few minutes at a low energy level.Erlenmeyer flasks were adequate reaction vessels since neither high pressure nor high temperature were involved.Fast monitoring of synthetic reactions was achieved by tlc separation and transfer of tlc spot material directly to a solids probe of a chemical ionization mass spectrometer.Microwave Oven-induced Reaction Enhancement (MORE) chemistry is not due to thermolysis: one reaction was conducted successfully in a reaction vial encased in a block of ice.

A Study and Mechanistic Interpretation of the Electronic and Steric Effects That Determine the Stereochemical Outcome of the Reaction of Schiff Bases with Homophthalic Anhydride and 3-Phenylsuccinic Anhydride

A study has been undertaken of the electronic and steric effects that determine the ratios of cis- and trans-isoquinolones 9 formed in the condensation of para-substituted Schiff bases 8 with homophthalic anhydride (5).A linear correlation between the rat