106728-60-3Relevant academic research and scientific papers
The continuous-flow synthesis of carbazate hydrazones using a simplified computer-vision controlled liquid–liquid extraction system
O'Brien, Matthew,Cooper, Dennis A.,Mhembere, Panashe
supporting information, p. 5188 - 5191 (2016/11/13)
A computer-vision controlled liquid–liquid extraction system was used in the continuous-flow synthesis of a series of carbazate hydrazones. The system uses open-source software components (Python, OpenCV) and is simpler and potentially more economical, in terms of hardware, than one we have described previously.
Design, synthesis and antiviral activity of novel pyridazines
Wang, Ziwen,Wang, Mingxiao,Yao, Xue,Li, Yue,Tan, Juan,Wang, Lizhong,Qiao, Wentao,Geng, Yunqi,Liu, Yuxiu,Wang, Qingmin
, p. 33 - 41 (2012/09/08)
A series of pyridazines were prepared and evaluated for their anti-HIV activity. The new synthetic route involving a novel rearrangement reaction provided a practical method for the preparation of 5-hydroxypyridazines. The primary bioassay results indicated that most of the pyridazines possess anti-HIV activity. It ought to been mentioned that the rearranged compounds 35 and 39 exhibited relatively higher HIV inhibitory effect. Most of the synthesized compounds were also found to possess good anti-TMV activity, of which compound 9 showed similar in vivo anti-TMV activity to commercial plant virucide Ribavirin. This work provides a new and efficient approach to evolve novel multi-functional antiviral agents by rational integration and optimization of previously reported antiviral agents.
1,3,4-Oxadiazolin-2-ones from Carbo-t-butoxyhydrazones
Baumgarten, Henry E.,Hwang, Deng-Ruey,Rao, T. N.
, p. 945 - 949 (2007/10/02)
5-Substituted-1,3,4-oxadiazolin-2-ones 2 were synthesized by the oxidation of carbo-t-butoxyhydrazones 1 of aromatic aldehydes with lead tetraacetate or, preferably, iodosobenzene diacetate.In some instances 5-acetoxy-1,3,4-oxadiazoles 3 were obtained along with 2.The oxidation of carboethoxyhydrazones 4 gave 2-ethoxy-1,3,4-oxadiazoles 5.
