106728-65-8

Basic information

• Product Name: Hydrazinecarboxylic acid, [(3,5-dimethoxyphenyl)methylene]-, 1,1-dimethylethyl ester
• CAS NO: 106728-65-8
• Molecular Formula: C14H20N2O4
• Molecular Weight: 280.324
• Mol File: 106728-65-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Hydrazinecarboxylic acid, [(3,5-dimethoxyphenyl)methylene]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarboxylic acid, [(3,5-dimethoxyphenyl)methylene]-, 1,1-dimethylethyl ester(106728-65-8)
• EPA Substance Registry System: Hydrazinecarboxylic acid, [(3,5-dimethoxyphenyl)methylene]-, 1,1-dimethylethyl ester(106728-65-8)

Safety Data

• Hazardous Substances Data: 106728-65-8(Hazardous Substances Data)

Upstream product

• 870-46-2 t-butoxycarbonylhydrazine 
• 7311-34-4 3,5-dimethoxybenzaldehdye 

Downstream Products

• 1372807-89-0 C₁₄H₂₂N₂O₄ 
• 1372807-73-2 C₂₁H₃₁N₃O₇ 
• 1372808-04-2 C₁₅H₁₉N₃O₄ 
• 1338091-84-1 (E)-tert-butyl 1-allyl-2-(3,5-dimethoxybenzylidene)hydrazinecarboxylate 
• 1338091-85-2 (E)-tert-butyl 1-benzyl-2-(3,5-dimethoxybenzylidene)hydrazinecarboxylate 
• 106728-68-1 5-(3,5-Dimethoxyphenyl)-1,3,4-oxadiazolin-2-one 

Relevant articles and documents

Synthesis and biological evaluation of Hydrazone derivatives as antifungal agents

Emerging yeasts are among the most prevalent causes of systemic infections with high mortality rates and there is an urgent need to develop specific, effective and non-Toxic antifungal agents to respond to this issue. In this study 35 aldehydes, hydrazones and hydrazines were obtained and their antifungal activity was evaluated against Candida species (C. parapsilosis, C.Tropicalis, C. krusei, C. albicans, C. glabrata and C. lusitaneae) and Trichosporon asahii, in an in vitro screening. The minimum inhibitory concentrations (MICs) of the active compounds in the screening was determined against 10 clinical isolates of C. parapsilosis and 10 of T. asahii. The compounds 4-pyridin-2-ylbenzaldehyde] (13a) and tert-butyl-(2Z)-2-(3,4,5-Trihydroxybenzylidine)hydrazine carboxylate (7b) showed the most promising MIC values in the range of 16-32 μg/mL and 8-16 μg/mL, respectively. The compounds' action on the stability of the cell membrane and cell wall was evaluated, which suggested the action of the compounds on the fungal cell membrane. Cell viability of leukocytes and an alkaline comet assay were performed to evaluate the cytotoxicity. Compound 13a was not cytotoxic at the active concentrations. These results support the discovery of promising candidates for the development of new antifungal agents.

1,3,4-Oxadiazolin-2-ones from Carbo-t-butoxyhydrazones

5-Substituted-1,3,4-oxadiazolin-2-ones 2 were synthesized by the oxidation of carbo-t-butoxyhydrazones 1 of aromatic aldehydes with lead tetraacetate or, preferably, iodosobenzene diacetate.In some instances 5-acetoxy-1,3,4-oxadiazoles 3 were obtained along with 2.The oxidation of carboethoxyhydrazones 4 gave 2-ethoxy-1,3,4-oxadiazoles 5.