1338091-85-2

Upstream product

• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 870-46-2 t-butoxycarbonylhydrazine 
• 106728-65-8 (E)-tert-butyl 2-(3,5-dimethoxybenzylidene)hydrazinecarboxylate 
• 100-39-0 benzyl bromide 

Relevant academic research and scientific papers

Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill

A large variety of Boc-, Bz-, Ts-, and Fmoc- protected hydrazones were prepared via condensation of an equimolar amount of carbonyl-compound and the corresponding hydrazine using a ball-mill. Hydrazones were always obtained in a quantitative yield and no solvents were used at any step. In a second step, we realized the first solvent-free N-allylation and N-benzylation of these hydrazones.