84725-13-3

Basic information

• Product Name: 5-Bromo-3-cyano-2-hydroxy-6-methylpyridine
• Synonyms: 5-Bromo-3-cyano-2-hydroxy-6-methylpyridine;3-Pyridinecarbonitrile, 5-broMo-1,2-dihydro-6-Methyl-2-oxo-;5-bromo-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile;5-BROMO-6-METHYL-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE(WXC05962);5-bromo-6-methyl-2-oxo-1H-pyridine-3-carbonitrile
• CAS NO: 84725-13-3
• Molecular Formula: C₇H₅BrN₂O
• Molecular Weight: 213.03
• Mol File: 84725-13-3.mol

Chemical Properties

• Boiling Point: 296.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.71±0.1 g/cm3(Predicted)
• PKA: 6.97±0.10(Predicted)
• CAS DataBase Reference: 5-Bromo-3-cyano-2-hydroxy-6-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-3-cyano-2-hydroxy-6-methylpyridine(84725-13-3)
• EPA Substance Registry System: 5-Bromo-3-cyano-2-hydroxy-6-methylpyridine(84725-13-3)

Safety Data

• Hazardous Substances Data: 84725-13-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-3-cyano-2-hydroxy-6-methylpyridine is used as an intermediate in the synthesis of pharmaceuticals for its potential role in the development of new drugs. Its unique structural and functional properties make it a valuable component in the creation of biologically active molecules.
Used in Agrochemical Industry:
In the agrochemical industry, 5-Bromo-3-cyano-2-hydroxy-6-methylpyridine is utilized as an intermediate in the synthesis of agrochemicals, contributing to the development of effective products for agricultural applications.
Used in Organic Chemistry Research and Synthesis:
5-Bromo-3-cyano-2-hydroxy-6-methylpyridine is also used as a key compound in organic chemistry research and synthesis, where it aids in the exploration and creation of novel chemical entities and reactions.

Upstream product

• 4241-27-4 2-hydroxy-6-methylnicotinonitrile 
• 4241-27-4 1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile 

Downstream Products

• 1265919-11-6 2-(benzyloxy)-5-bromo-6-methylnicotinonitrile 
• 106730-54-5 olprinone 
• 78415-72-2 1,6-dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile 
• 717832-82-1 5-(3-chloro-phenyl)-6-[(4-cyano-phenyl)-(1-trityl-1H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile 

Relevant articles and documents

PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, R6, R5, G1, and G2 are defined herein.

A method for synthesizing milrinone

The invention discloses a new method for synthesizing milrinone. The method is characterized in that a compound of formula 3 and 4-pyridineboronic acid undergo a Suzuki coupling reaction to synthesize milrinone. The method has the advantages of easily available raw materials, high yield and simple post-treatment.

THIENOPYRIDINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS

The disclosure relates to inhibitors of USP28 and/or USP25 useful in the treatment of cancers, inflammation, autoimmune diseases, and infectious diseases, having the Formula (I), where R1, R2, R3, R4, R5, R5', R6, R7, X, m, and n are described herein.

Preparation method of olprinone and 9-azaindole-5-boric acid

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CONDENSED TRICLYCLIC COMPOUNDS AS INHIBITORS OF HIV REPLICATION

Compounds of formula (I) and pharmaceutical compositions thereof: wherein A1 A2 and A3 are each independently selected from the group consisting of N and CR3, wherein R1 is an optionally substituted heterocyclyl or an optionally substituted -(C1-6)alkyl-heterocyclyl, R2 is an optionally substituted aryl or an optionally subsisted heteroaryl, R4 is an optionally substituted aryl, an optionally substituted heterocyclyl or an optionally substituted heteroaryl, useful as an inbitor of HIV replication.

Synthesis of amido-N-imidazolium salts and their applications as ligands in suzuki-miyaura reactions: Coupling of hetero- aromatic halides and the synthesis of milrinone and irbesartan

A new catalytic system based on palladium-amido-N-heterocyclic carbenes for Suzuki-Miyaura coupling reactions of heteroaryl bromides is described. A variety of sterically bulky, amido-N-imidazolium salts were synthesized in high yields from the corresponding anilines. This catalytic system effectively promoted Suzuki-Miyaura couplings of heteroaryl bromides and chlorides with a range of boronic acids to give the corresponding aryl compounds in high yield. The yield was increased with increasing steric bulkiness of the substituted group. Especially, 1-(2,6-diisopropylphenyl)-3-N-(2,4,6-tri-tert- butylphenylacetamido)imidazolium bromide (4bc) exhibited 850,000 TON in the coupling reaction of 2-bromopyridine and phenylboronic acid. In addition, pharmaceutical compounds such as milrinone and irbesartan were synthesized via Suzuki-Miyaura coupling using sterically bulky, amido-N-imidazolium salt (4bc) as a ligand. Copyright

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A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as 4), resulting in potent inhibitors with improved pharmacokinetics.

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Farnesyltransferase inhibitors

Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

Farnesyltransferase inhibitors

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