106746-01-4

Upstream product

• 106942-34-1 2-phenyl-4-phenylethyl-5(4H)-oxazolone 
• 98-88-4 benzoyl chloride 
• 1012-05-1 D,L-homophenylalanine 
• 106942-41-0 4-Phenethyl-2-phenyl-4-(2,2,2-trifluoro-acetyl)-4H-oxazol-5-one 
• 88058-32-6 2-benzoylamino-4-phenyl-butyric acid 

Relevant academic research and scientific papers

SYNTHESIS OF FLUORINATED α-AMINO KETONES PART I: α-BENZAMIDOALKYL MONO- DI- AND TRIFLUOROMETHYL KETONES

2-Phenyl-5(4H)-oxazolones, obtained from α-amino acids, are reacted with di- and trifluoro acetic anhydride by a modified Dakin-West procedure to yield in a one-pot reaction α-benzamidoalkyl-di- and trifluoromethyl ketones in good yields.The monofluoromethyl analogues were also prepared from α-amino acids, however the use of the highly toxic fluoroacetic anhydride was avoided.The key step is the halogen exchange reaction on the corresponding bromomethyl ketone.