106762-44-1Relevant articles and documents
Sulfonylation from sodium dithionite or thiourea dioxide
He, Fu-Sheng,Yang, Min,Ye, Shengqing,Wu, Jie
, p. 461 - 464 (2020/06/03)
The cheap and easily available sodium dithionite and thiourea dioxide have been used as the source of sulfonyl group in the synthesis of sulfones and sulfonamides recently. Compared with other methods for the sulfonylation reactions, the strategies using sodium dithionite or thiourea dioxide provide an alternative and complementary route to diverse sulfonyl compounds. During the reaction process, sulfur dioxide anion radical is the key intermediate, which is usually generated from a single electron transfer under suitable conditions. The advantages using sodium dithionite or thiourea dioxide in the sulfonylation reactions include mild conditions and broad substrate scope with excellent functional group compatibility. Further applications by using sodium dithionite and thiourea dioxide in organic transformations will be anticipated.
A [...] or heterocyclic sulfonamide compound preparation method (by machine translation)
-
Paragraph 0090; 0091; 0092; 0093; 0094, (2019/01/21)
The invention discloses a [...] or heterocyclic sulfonamide compounds of the preparation method, the [...] compound has the formula (I) of the structure shown, the heterocyclic and tissue compound has the formula (II) is shown in the structure, in an organic solvent under the condition of a portion of the inert gas, iodo aromatic ring compound and sodium hydrosulfite under heating conditions in the free radical coupling reaction to obtain the aromatic ring sulfinyl sodium intermediate, with the [...], or iodo alkane, or bromo alkane, or diaryl Iodized salt, or [...] reaction, obtained by the formula (I) has the structure shown as the [...], or formula (II) has the structure shown in the heterocyclic sulfonamide compounds. The method of the invention is simple and efficient, less side reaction, the product has high purity, facilitates separation of the purification, can be suitable for the preparation of a larger scale, with very good application prospect. (by machine translation)
Method for preparing heterocyclic sulfone or heterocyclic sulfamide compound
-
Paragraph 0134-0141, (2019/04/04)
The invention belongs to the technical field of organic synthesis. The invention provides a method for preparing a heterocyclic sulfone or heterocyclic sulfamide compound. The method comprises the following steps: firstly, in a protection atmosphere, under the condition of visible light radiation, carrying out a free radical coupling reaction on an iodo-heteroaromatic compound, thiourea dioxide and sodium hydroxide so as to obtain aromatic heterocyclic sodium sulfinate, wherein a catalyst used in the free radical coupling reaction is fluorescein; and secondly, maintaining a protection atmosphere, carrying out an alkylation reaction or an amidation reaction on the aromatic heterocyclic sodium sulfinate and a group donor compound, thereby obtaining heterocyclic sulfone or heterocyclic sulfamide, wherein the group donor compound is a halogen compound, diaryl or an amino organic matter. The heterocyclic sulfone or the heterocyclic sulfamide can be prepared by only two steps of reactions byusing the method provided by the invention, and in addition, no strong corrosive substance is used, and the method is small in byproduct amount and high in yield.