106762-91-8

Basic information

• Product Name: (1R,2R,4S)-2-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-4-(hydroxymethyl)cyclopentanol
• CAS NO: 106762-91-8
• Molecular Formula: C₁₀H₁₅N₇O₂
• Molecular Weight: 265.2718
• Mol File: 106762-91-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 702°C at 760 mmHg
• Flash Point: 378.4°C
• Density: 2.1g/cm³
• Vapor Pressure: 1.1E-20mmHg at 25°C
• Refractive Index: 1.994
• CAS DataBase Reference: (1R,2R,4S)-2-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-4-(hydroxymethyl)cyclopentanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R,4S)-2-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-4-(hydroxymethyl)cyclopentanol(106762-91-8)
• EPA Substance Registry System: (1R,2R,4S)-2-(5,7-diamino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-4-(hydroxymethyl)cyclopentanol(106762-91-8)

Safety Data

• Hazardous Substances Data: 106762-91-8(Hazardous Substances Data)

Upstream product

• 106762-84-9 (1R,2R,4S)-2-[2-Amino-6-chloro-5-(4-chloro-phenylazo)-pyrimidin-4-ylamino]-4-hydroxymethyl-cyclopentanol 
• 106762-83-8 (+/-)-(1α,3α,4β)-3-<(2-amino-6-chloro-4-pyrimidinyl)amino>-4-hydroxycyclopentamethanol 
• 106762-85-0 (+/-)-(1α,3α,4β)-3-<(2,5-diamino-6-chloro-4-pyrimidinyl)amino>-4-hydroxycyclopentanemethanol 
• 68715-64-0 (+/-)-(1α,3α,4β)-3-amino-4-hydroxycyclopentanemethanol 
• 106762-87-2 (+/-)-(1α,3α,4β)-3-(5-amino-7-chloro-3H-1,2,3-triazolo<4,5-d>pyrimidin-3-yl)-4-hydroxycyclopentanemethanol 

Relevant articles and documents

Synthesis and Antiviral Evaluation of Carboxylic Analogues of 2-Amino-6-substituted-purine 3'-Deoxyribofuranosides

Carbocyclic analogues of 2-amino-6-substituted-purine 3'-deoxyribofuranosides were synthesized by beginning with (+/-)-(1α,3α,4β)-3-amino-4-hydroxycyclopentanemethanol and 2-amino-4,6-dichloropyrimidine.The route parallels the earlier syntheses of the corresponding ribofuranoside and 2'-deoxyribofuranoside analogues.The 2-amino-6-chloropurine, guanine, and 2,6-diaminopurine derivatives and the analogous 8-azapurines were prepared.The analogue (3'-CDG) of 3'-deoxyguanosine is active in vitro against a strain of type 1 herpes simplex virus (HSV-1) that induces thymidine kinase and is modestly active against a thymidine kinase inducing strain of type 2-HSV. 3'-CDG is not active against a strain of HSV-1 that lacks the thymidine kinase inducing capacity, whereas the carbocyclic analogue of 2 amino-6-chloropurine 3'-deoxyribofuranoside is active against that strain.The carbocyclic analogue of 2,6-diaminopurine 3'-deoxyribofuranoside displayed modest activity in vitro against influenza virus.