1067640-95-2Relevant academic research and scientific papers
Regioselective modification of amino groups in aminoglycosides based on cyclic carbamate formation
Chen, Guihui,Pan, Pan,Yao, Yun,Chen, Ying,Meng, Xiangbao,Li, Zhongjun
, p. 9078 - 9087 (2008/12/22)
Conditions for regioselective introduction of cyclic carbamate into per-N-Cbz neamine and per-N-Cbz kanamycin A have been found. The position and number of cyclic carbamate formed in these two aminoglycosides was controllable. On the base of selective cyclic carbamate formation, regioselective modification on N-1, N-6′ or both amino groups in neamine, and on N-6′, N-3″ or both amino groups in kanamycin A was achieved by ring-opening reaction with amines. A new neamine dimer linked at the N-1 was also synthesized with this method.
