1067649-06-2Relevant academic research and scientific papers
Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation
Debenham, John S.,Madsen-Duggan, Christina B.,Wang, Junying,Tong, Xinchun,Lao, Julie,Fong, Tung M.,Schaeffer, Marie-Therese,Xiao, Jing Chen,Huang, Cathy C.R.-R.,Shen, Chun-Pyn,Sloan Stribling,Shearman, Lauren P.,Strack, Alison M.,Euan MacIntyre,Hale, Jeffrey J.,Walsh, Thomas F.
scheme or table, p. 2591 - 2594 (2009/12/25)
The synthesis, SAR and binding affinities are described for cannabinoid-1 receptor (CB1R) specific inverse agonists based on pyridopyrimidine and heterotricyclic scaffolds. Food intake and pharmacokinetic evaluation of several of these compounds indicate
SUBSTITUTED PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS CANNABINOID-1 RECEPTOR MODULATORS
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, (2008/12/04)
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present in
