7504-29-2

Usage

Uses

Used in Pharmaceutical Research:
1-(2-chlorophenyl)-2-(4-chlorophenyl)ethanone is used as a building block for the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable intermediate in the development of a wide range of medicinal compounds.
Used in Agrochemicals:
In the agrochemical industry, 1-(2-chlorophenyl)-2-(4-chlorophenyl)ethanone is utilized as a key component in the creation of different agrochemicals, contributing to its importance in this sector.
Used in Organic Synthesis:
As a reagent, 1-(2-chlorophenyl)-2-(4-chlorophenyl)ethanone is employed in the preparation of other organic compounds, highlighting its versatility and applicability in organic chemistry.
Used in Chemical Production:
1-(2-chlorophenyl)-2-(4-chlorophenyl)ethanone serves as an important intermediate in the production of a broad spectrum of chemicals, underlining its significance in the chemical industry.

Upstream product

• 873-32-5 2-Chlorobenzonitrile 
• 107323-82-0 4-chlorobenzylmagnesium bromide 
• 609-66-5 2-chlorobenzamide 
• 609-65-4 o-chlorobenzoyl chloride 
• 622-95-7 4-chlorobenzyl bromide 
• 26037-50-3 tri(4-chloro)benzyl aluminium 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 654668-43-6 1-(2-chlorophenyl)-2-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one 
• 916728-81-9 2-bromo-1-(2-chlorophenyl)-2-(4-chlorophenyl)-ethanone 
• 611220-83-8 6-(2-chlorophenyl)-5-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 611220-89-4 2-chloro-6-(2-chlorophenyl)-5-(4-chlorophenyl)-pyridine-3-carbonitrile 
• 1065267-58-4 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4-amine 
• 1065267-60-8 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one 
• 1065267-61-9 2-tert-butyl-4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine 
• 1065267-63-1 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)-4-hydrazinopyrido[2,3-d]pyrimidine 
• 1065266-53-6 5-tert-butyl-8-(2-chlorophenyl)-9-(4-chlorophenyl)pyrido[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine 
• 1067649-52-8 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-4-carbonitrile 
• 1067649-53-9 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)-4-(4-fluorophenyl)pyrido[2,3-d]pyrimidine 
• 1067649-54-0 methyl 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-4-carboxylate 
• 1067649-55-1 ethyl 4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-2-carboxylate 
• 1067649-57-3 2-amino-6-(2-chlorophenyl)-5-(4-chlorophenyl)nicotinonitrile 

Relevant academic research and scientific papers

Tandem nucleophilic addition-Oppenauer oxidation of aromatic aldehydes to aryl ketones with triorganoaluminium reagents

In the presence of pinacolone, the in situ prepared triorganoaluminium reagents reacted with aromatic aldehydes to give ketones in moderate to high yield. We propose that the products are formed via a tandem organoaluminium reagents addition-Oppenauer oxidation sequence. The Royal Society of Chemistry 2013.

Development of two synthetic routes to CE-178,253, a CB1 antagonist for the treatment of obesity

CE-178,253 benzenesulfonate (1) is a CB1 antagonist discovered by Pfizer medicinal chemists. Two syntheses of this compound are described. The first, based on the discovery synthesis, involves assembly of an aryl-substituted pyrazolotriazine core onto which the second aryl moiety is installed by a Suzuki coupling; this route has been scaled to provide up to 6 kg of API. A second, more convergent route is also described, which installs the pyrazolotriazine containing both aryl substituents by condensation of a bromoketone with a substituted thiosemicarbazide. This route has been demonstrated on laboratory scale and is viewed as the preferred bond-forming sequence.

PREPARATION OF 3-AMINO-4,5-DISUBSTITUTED-PYRAZOLE DERIVATIVES

A process for preparing a compound of Formula (I) is described herein as well as rocesses for using this compound to prepare other useful intermediates and compounds.