1067658-27-8

Basic information

• Product Name: (R)-b-AMino-4-chloro-benzeneethanol
• Synonyms: (R)-b-AMino-4-chloro-benzeneethanol;(2R)-2-AMINO-2-(4-CHLOROPHENYL)ETHAN-1-OL;(R)-2-amino-2-(4-chlorophenyl)ethan-1-ol
• CAS NO: 1067658-27-8
• Molecular Formula: C₈H₁₀ClNO
• Molecular Weight: 171.6241
• Mol File: 1067658-27-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 319.8±27.0 °C(Predicted)
• Appearance: /
• Density: 1.260±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.43±0.10(Predicted)
• CAS DataBase Reference: (R)-b-AMino-4-chloro-benzeneethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-b-AMino-4-chloro-benzeneethanol(1067658-27-8)
• EPA Substance Registry System: (R)-b-AMino-4-chloro-benzeneethanol(1067658-27-8)

Safety Data

• Hazardous Substances Data: 1067658-27-8(Hazardous Substances Data)

Usage

General Description

(R)-b-Amino-4-chloro-benzeneethanol is a chemical compound with the molecular formula C8H10ClNO. It is a chiral compound, with two enantiomers designated as (R)- and (S)-. (R)-b-AMino-4-chloro-benzeneethanol is a derivative of 4-chlorophenethylamine, and it is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is also utilized as a chiral resolving agent for the separation of racemic mixtures. Additionally, (R)-b-Amino-4-chloro-benzeneethanol has potential applications in the field of medicinal chemistry due to its ability to bind to specific biological targets, making it of interest for drug discovery and development. Overall, this compound has diverse and important chemical and pharmaceutical applications.

Upstream product

• 1268337-06-9 (R)-2-azido-2-(4-chlorophenyl)ethan-1-ol 
• 179065-35-1 (S)?2?bromo?1?(4′?chlorophenyl)ethanol 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 2788-86-5 (2S)-2-(4-chlorophenyl)oxirane 
• 43189-37-3 (R)-2-amino-2-(4-chlorophenyl)acetic acid 
• 59410-89-8 (R)-2-(4-chlorophenyl)glycine methyl ester hydrochloride 

Downstream Products

• 1395847-77-4 (S)-4-tert-butyl 1-((R)-2-(4-chlorophenyl)-2-(pent-4-enamido)ethyl) 2-allylsuccinate 
• 1395847-80-9 tert-butyl 2-((3R,11S,E)-3-(4-chlorophenyl)-5,12-dioxo-1-oxa-4-azacyclododec-8-en-11-yl)acetate 
• 1396152-06-9 N-(4-chlorobenzyl)-2-((3R,11S,E)-3-(4-chlorophenyl)-5,12-dioxo-1-oxa-4-azacyclododec-8-en-11-yl)acetamide 
• 1395847-72-9 (R)-N-(1-(4-chlorophenyl)-2-hydroxyethyl)pent-4-enamide 
• 1043493-37-3 (S)-4-(4-chlorophenyl)-4,5-dihydrooxazol-2-ylamine 
• 1429397-50-1 (1R,2R)-2-amino-1-(3-chlorophenyl)-2-(4-chlorophenyl)ethanol hydrochloride 
• 1429387-27-8 tert-butyl (1R,2R)-2-(3-chlorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylcarbamate 
• 1429382-73-9 tert-butyl (1R,2R)-2-(3-chloro-5-fluorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylcarbamate 
• 1429382-74-0 tert-butyl (1R,2S)-2-(3-chloro-5-fluorophenyl)-1-(4-chlorophenyl)-2-hydroxyethylcarbamate 
• 1429382-72-8 (R)-tert-butyl 1-(4-chlorophenyl)-2-oxoethylcarbamate 
• 1429382-71-7 (R)-tert-butyl (1-(4-chlorophenyl)-2-hydroxyethyl)carbamate 

Relevant articles and documents

Enantioselective Copper Catalyzed Alkyne-Azide Cycloaddition by Dynamic Kinetic Resolution

The copper(I) catalyzed alkyne-azide cycloaddition (CuAAC), a click reaction, is one of the most powerful catalytic reactions developed during the last two decades. Conducting CuAAC enantioselectively would add a third dimension to this reaction and would

Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction

We previously reported the discovery of AMG 232, a highly potent and selective piperidinone inhibitor of the MDM2-p53 interaction. Our continued search for potent and diverse analogues led to the discovery of novel morpholinone MDM2 inhibitors. This change to a morpholinone core has a significant impact on both potency and metabolic stability compared to the piperidinone series. Within this morpholinone series, AM-8735 emerged as an inhibitor with remarkable biochemical potency (HTRF IC50 = 0.4 nM) and cellular potency (SJSA-1 EdU IC50 = 25 nM), as well as pharmacokinetic properties. Compound 4 also shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with an ED50 of 41 mg/kg. Lead optimization toward the discovery of this inhibitor as well as key differences between the morpholinone and the piperidinone series will be described herein.

Electronic effects of aryl-substituted bis(oxazoline) ligands on the outcome of asymmetric copper-catalysed C-H insertion and aromatic addition reactions

The effect of the modification of bis(oxazoline) ligands on the outcome of copper-catalysed C-H insertion and aromatic addition reactions is described. In general, these reactions display minimum sensitivity in terms of enantiocontrol to variation of the electronic properties of the aryl moiety of the ligand however, some influence is observed for C-H insertions employing naphthyl-substituted bis(oxazolines) and for aromatic addition reactions of biphenyl diazo ketone substrates. The synthesis of the modified bis(oxazolines), which include four novel structures, is also described.