106787-35-3Relevant academic research and scientific papers
Synthesis of phosphonodipeptide conjugates of ursolic acid and their homologs
Deng, Sheng-Lou,Baglin, Isabelle,Nour, Mohammed,Cave, Christian
, p. 55 - 65 (2008/04/05)
To prepare novel derivatives of naturally bioactive 3β-hydroxy-urs-12- en-28-oic acid (ursolic acid) with unusual properties and broad spectrum of activities, a number of chemical reactions were conducted. First, a variety of a-aminophosphonates were prepared by a series of reactions involving the three-component Mannich type reaction as a key step. Second, an array of phosphonodipeptides and their homologs was synthesized through multistep reactions including condensation of phthalic anhydride with glycine or β-alanine, chlorination of N-blocked amino acids, coupling of acid chloride with α-aminophosphonates and sequential hydrazinolysis. Finally, new classes of phosphonodipeptide conjugates of ursolic acid and their homologs were obtained by condensation of 3β-acetoxy-urs-12-en-28-oyl chloride with phosphonodipeptides and their homologs.
Synthesis of ursolic phosphonate derivatives as potential anti-HIV agents
Deng, Sheng-Lou,Baglin, Isabelle,Nour, Mohammed,Flekhter, Oxana,Vita, Claudio,Cave, Christian
, p. 951 - 967 (2008/02/01)
In order to search for new anti-tumor and anti-viral agents, a series of -aminophosphonate conjugates of 3-O - acetyl ursolic acid were prepared. Their biological activities as cytotoxic and anti-HIV agents were evaluated. The preliminary bioassays indicate that synthesized compounds 7a-j have anti-HIV activity (targeting HIV-1 gp120 and CD4) and no cytotoxicity on HT-29 cells (human colon adenocarcinoma cell line).
Studies on Organophosphorus Compounds; Part XX. A Facile Synthesis of α-Amino-Substituted Benzylphosphonic and -phosphinic Acids by Use of Thiophosphoramide
Yuan, Chengye,Qi, Youmao
, p. 821 - 825 (2007/10/02)
A facile method for the preparation of α-amino-substituted benzylphosphonic and -phosphinic acids is reported.It consists of the reaction of O,O-diethyl or O-ethyl O-phenyl phosphoroamidothioate (1) with a substituted benzaldehyde (2) and a phosphorous or
