106809-17-0

Upstream product

• 106809-15-8 ethyl (2,4-dichloro-5-fluoro-3-nitrobenzoyl)acetate 
• 122-51-0 orthoformic acid triethyl ester 
• 106809-16-9 diethyl (2,4-dichloro-5-fluoro-3-nitro-benzoyl)-malonate 
• 86522-89-6 2,4-dichloro-5-fluoro-benzoic acid 
• 104600-29-5 2,4-dichloro-5-fluoro-3-nitro-benzoyl chloride 
• 106809-14-7 2,4-dichloro-5-fluoro-3-nitro-benzoic acid 

Downstream Products

• 109308-99-8 2-(2,4-Dichlor-5-fluor-3-nitrobenzoyl)-3-(2-formyl-2-methylhydrazino)acrylsaeure-ethylester 
• 117239-36-8 ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-chloro-8-nitro-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 117239-42-6 ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(4-methylpiperazin-1-yl)-8-amino-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 117239-38-0 ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(3-acetamidopyrrolidin-1-yl)-8-amino-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 117257-83-7 ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(4-methylpiperazin-1-yl)-8-nitro-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 117239-37-9 ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(3-acetamidopyrrolidin-1-yl)-8-nitro-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 109308-89-6 3-(Dimethylhydrazino)-2-(2,4-dichlor-5-fluor-3-nitrobenzoyl)-acrylsaeure-ethylester 
• 117239-35-7 (E)-2-(2,4-Dichloro-5-fluoro-3-nitro-benzoyl)-3-(2,4-difluoro-phenylamino)-acrylic acid ethyl ester 
• 111453-56-6 ethyl 3-(N-cyclopropylamino)-2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl) acrylate 
• 107358-97-4 ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-<1-hydroxymethyl(ethylamino)>acrylate 

Relevant academic research and scientific papers

Defluorinated sparfloxacin as a new photoproduct identified by liquid chromatography coupled with UV detection and tandem mass spectrometry

Photodegradation of sparfloxacin was observed by means of high-pressure liquid chromatography with UV detection and liquid chromatography coupled with UV detection and tandem mass spectrometry (LC-MS/MS). Three products were detected. Comparison with an independently synthesized derivative of sparfloxacin revealed the structure of one product which is believed to be 8- desfluorosparfloxacin. The second product is likely to be formed by the splitting off of a fluorine and a cyclopropyl ring. Thus, photodefluorination of quinolone antibacterial agents is found and proved for the first time by LC-MS/MS.

STRUCTURAL MODIFICATION AND NEW METHODS FOR PREPARATION OF OFLOXACIN ANALOGS

Reaction of ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxyacrylate IIb with 2-amino-1-propanol provided corresponding compound IIIb which under alkaline conditions underwent an aromatic denitrocyclization reaction which after alkaline saponificat

4-Hydroxy-quinoline-3-carboxylic

A process for the preparation of a compound of the formula STR1 in which Y is a nitrile group, an ester group COOR1 or an acid amide CONR2 R3, R1, R2 and R3 each independently is hydrogen or C1 -C4 -alkyl, and R3 may also be phenyl, and X2, X3, X4 and X5 each independently is hydrogen, halogen, nitro, cyano, alkyl having 1-3 carbon atoms, alkoxy having 1-3 carbon atoms, alkylmercapto having 1-3 carbon atoms, alkylsulphonyl having 1-3 carbon atoms, or a phenylsulphonyl group which is optionally substituted in the aryl radical, comprising reacting an aminoacrylate of the formula in which X1 is halogen, a nitro group, an alkoxy, alkoxy, alkylmercapto or alkylsulphonyl group having 1-3 carbon atoms in each case, or an arylsulphonyl group, W is hydrogen or a --CH2 CH2 Z radical, Z is is a nitrile group, an ester group COOR4 or an acid amide group CONR5 R6, and R4, R5 and R6 each independently is hydrogen or C1 -C4 -alkyl, and R5 may also be phenyl, with an acid acceptor in an aprotic solvent. Some of the reactants are new, as are the products which are intermediates for antibacterially active 1-alkyl-4-quinolone-3-carboxylic acids.

Synthesis of 4,12-Dihydro-4-oxoquinoquinoxaline-5-carboxylic Acid Derivatives

The synthesis and antibacterial activity of 1-substituted amino-2-fluoro-4,12-dihydro-4-oxoquinoquinoxaline-5-carboxylic acid derivatives are described.The synthetic route includes a carbon homologation and two intramolecular nucleophilic disp