106809-15-8

Upstream product

• 1071-46-1 hydrogen ethyl malonate 
• 104600-29-5 2,4-dichloro-5-fluoro-3-nitro-benzoyl chloride 
• 86522-89-6 2,4-dichloro-5-fluoro-benzoic acid 
• 106809-14-7 2,4-dichloro-5-fluoro-3-nitro-benzoic acid 
• 106809-16-9 diethyl (2,4-dichloro-5-fluoro-3-nitro-benzoyl)-malonate 

Downstream Products

• 106809-17-0 ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxyacrylate 
• 117239-36-8 ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-chloro-8-nitro-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 117239-35-7 (E)-2-(2,4-Dichloro-5-fluoro-3-nitro-benzoyl)-3-(2,4-difluoro-phenylamino)-acrylic acid ethyl ester 
• 117239-42-6 ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(4-methylpiperazin-1-yl)-8-amino-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 117239-38-0 ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(3-acetamidopyrrolidin-1-yl)-8-amino-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 117257-83-7 ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(4-methylpiperazin-1-yl)-8-nitro-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 117239-37-9 ethyl 1-(2,4-difluorophenyl)-6-fluoro-7-(3-acetamidopyrrolidin-1-yl)-8-nitro-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 107358-97-4 ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-<1-hydroxymethyl(ethylamino)>acrylate 

Relevant academic research and scientific papers

Defluorinated sparfloxacin as a new photoproduct identified by liquid chromatography coupled with UV detection and tandem mass spectrometry

Photodegradation of sparfloxacin was observed by means of high-pressure liquid chromatography with UV detection and liquid chromatography coupled with UV detection and tandem mass spectrometry (LC-MS/MS). Three products were detected. Comparison with an independently synthesized derivative of sparfloxacin revealed the structure of one product which is believed to be 8- desfluorosparfloxacin. The second product is likely to be formed by the splitting off of a fluorine and a cyclopropyl ring. Thus, photodefluorination of quinolone antibacterial agents is found and proved for the first time by LC-MS/MS.

Synthesis of 4,12-Dihydro-4-oxoquinoquinoxaline-5-carboxylic Acid Derivatives

The synthesis and antibacterial activity of 1-substituted amino-2-fluoro-4,12-dihydro-4-oxoquinoquinoxaline-5-carboxylic acid derivatives are described.The synthetic route includes a carbon homologation and two intramolecular nucleophilic disp