106849-47-2

Upstream product

• 108895-98-3 benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 74-88-4 methyl iodide 

Downstream Products

• 1229611-66-8 ethyl 8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoate 
• 1346678-79-2 8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoic acid 
• 1449305-58-1 9-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-ylamino)-9-oxononanoic acid 
• 1449305-59-2 C₂₄H₂₇N₃O₄ 
• 1449305-60-5 6-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-ylamino)-6-oxohexanoic acid 
• 1449305-61-6 7-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-ylamino)-7-oxoheptanoic acid 
• 1449305-62-7 N¹-hydroxy-N⁸-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)nonanediamide 
• 1229611-67-9 N¹-Hydroxy-N⁹-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)octanediamide 
• 1449305-63-8 N¹-Hydroxy-N⁶-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)hexanediamide 
• 1449305-64-9 N¹-Hydroxy-N⁷-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)heptanediamide 
• 103343-65-3 (3R)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one 
• 1229611-69-1 (R)-ethyl 8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoate 
• 1449305-66-1 (R)-8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoic acid 
• 134793-38-7 [2-(4-Hydroxy-phenyl)-1-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Design, synthesisand preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring

A series of new histone deacetylase inhibitors were designed and synthesized based on hybridization between SAHA or oxamflatin and 5-phenyl-1,4-benzodiazepines. The compounds were tested for their enzyme inhibitory activity on HeLa nuclear extracts, and o

5-PHENYL-LH-BENZ0 [E] [1, 4] DIAZEPINE COMPOUNDS SUBSTITUTED WITH AN HYDROXAMIC ACID GROUP AS HISTONE DEACETYLASE INHIBITORS

Novel hydroxamate histone deacetylase inhibitors of formula (I) wherein X is C=O or CH2 used as antineoplastic agent.