1068614-44-7

Upstream product

• 2689-88-5 diethyl 2,2-di(prop-2-yn-1-yl)malonate 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 105-53-3 diethyl malonate 
• 536-74-3 phenylacetylene 

Downstream Products

• 1577232-37-1 diethyl 7-bromo-5-phenyl-4-(phenylethynyl)-1H-indene-2,2(3H)-dicarboxylate 
• 1577232-38-2 diethyl 7-chloro-5-phenyl-4-(phenylethynyl)-1H-indene-2,2(3H)-dicarboxylate 
• 1577232-39-3 diethyl 7-iodo-5-phenyl-4-(phenylethynyl)-1H-indene-2,2(3H)-dicarboxylate 

Relevant academic research and scientific papers

Phenanthrenes/dihydrophenanthrenes: The selectivity controlled by different benzynes and allenes

A method for the intermolecular annulation of benzynes with allenes is disclosed. This protocol utilized allenes as an unconventional diene component for the selective synthesis of phenanthrenes and dihydrophenanthrenes under the control of different benzyne precursors, featuring high atom-economy and good functional group compatibility. Density functional theory (DFT) calculations reveal that different migratory routes of the aromatic C-H bond are crucial for the observed selectivity. This journal is

Access to Benzoxazepines and Fully Substituted Indoles via HDDA Coupling

The HDDA-derived benzyne intermediate was captured by oxazolines based on the addition reaction of benzyne to the Ca?N double bond. Benzoxazepine derivatives, fused benzoxazepine derivatives, and fully substituted indoles are synthesized in one step. The reaction does not require any catalyst or additives. Possible reaction mechanisms are presented.

Fully Substituted Conjugate Benzofuran Core: Multiyne Cascade Coupling and Oxidation of Cyclopropenone

An unprecedented C═C double bond cleavage of cyclopropenone and dioxygen activation by multiyne cascade coupling has been developed. This chemistry provides a novel, simple, and efficient approach to synthesize fully substituted conjugate benzofuran derivatives from simple substrates under mild conditions. The density functional theory (DFT) calculations reveal that the unique homolytic cleavages of cyclopropenone and molecular oxygen are crucial to the success of this reaction.

Epoxyanthracene Derivatives and Dicarbonylation on Benzene Ring via Hexadehydro-Diels-Alder (HDDA) Derived Benzynes with Oxazoles

A capture reaction of hexadehydro-Diels-Alder (HDDA) derived benzyne with various substituted oxazoles is reported. With methyl, hydrogen, or phenyl as the substituent at 2-position of oxazole, tetraynes afforded epoxyanthracene derivatives or underwent dicarbonylation on benzene ring. The reaction does not require any catalyst or additive. The mechanism behind the reaction was investigated. The obtained polycyclic product structure has potential application value in optoelectronic materials. The availability of dicarbonylated arene implies the uniqueness of HDDA benzyne reaction compared with traditional benzyne.

2-aldehyde indole compound and preparation method thereof

The invention provides a 2-aldehyde indole compound and a preparation method thereof. The 2-aldehyde indole compound is obtained by taking a tetraacetylene compound and 2-phenyl-2-oxazoline as raw materials and reacting in a toluene solvent. Compared with the prior art, the invention provides a brand-new synthesis method of 2-formyl indole, and a new 2-formyl indole compound is generated. The synthesized 2-aldehyde indole compound has relatively high atom economy, is more complex and diverse in structure, and has a certain application prospect.

Multi-[...] ether derivatives and its preparation method (by machine translation)

The invention relates to the field of organic synthesis, and especially relates to a multi-[...] ether derivatives and its preparation method. The multi-[...] ether derivatives to the ordinary selenide derivatives is the existence of multi-ring, its structure is more complex, in the chemical industry, in clinical medicine also will show more extensive use prospect. In the method for preparing the oxygen free system, the two alkyne class compound, aryl alkyne bromine, anhydrous acetonitrile, transition metal catalyst and organic alkali mixing and reaction intermediates. In the 115 - 125 °C conditions, the intermediate, diphenyl diselenides and toluene mixing and reaction. Preparation method overcomes the reaction route in the past is too long, the substrate and the harsh reaction conditions, substituted functional group extends the limited and the like. (by machine translation)

The exocyclic double bond of a nitrogen-containing heterocyclic derivatives and its preparation method (by machine translation)

The invention provides a of the exocyclic double bond oxygen and nitrogen heterocyclic derivatives and its preparation method, the preparation method is: the four-alkyne apperception compound in toluene solvent with 2, 4, 4 - trimethyl - 2 - oxazoline heating reaction, after the reaction, natural cooling to room temperature, the product purification and separation, by the outer double bond containing an oxygen and nitrogen heterocyclic derivatives. Compared with the prior art, the present invention provides a series of new containing an outer double bond of the oxygen and nitrogen heterocyclic derivatives of the preparation method. As to the ordinary heterocyclic derivatives, the preparation of the invention containing an outer double bond of nitrogen heterocyclic derivatives have the exocyclic double bond and the existence of effinity atoms, and get the rare of the seven-membered ring structure, its structure is more complex and novel. The invention material may be in the in medical industry also can have a broader role, and the present invention provides a preparation method, high-efficiency, short reaction time, efficiency is high. (by machine translation)

Exocyclic double-bond quinoline derivative and preparation method thereof

The invention discloses an exocyclic double-bond quinoline derivative and a preparation method thereof. A tert-acetylene compound and (s)-(4-isopropyl oxazoline-2-yl) ferrocene are adopted as raw materials, and in a methylbenzene solvent, a reaction is carried out for 8-14 hours at 100-110 DEG C, so that the exocyclic double-bond quinoline derivative of a complex structure can be synthesized. Compared with the prior art, the invention provides a bran-new exocyclic double-bond quinoline synthesis method, and a series of novel exocyclic double-bond quinoline derivatives are generated. The synthesized exocyclic double-bond quinoline derivative has high atom economy, has complex and diverse structures, and has certain application prospects.

A method for containing tri aryl phosphorus oxygen class ligand and its preparation method (by machine translation)

The invention discloses a method for containing tri aryl phosphorus oxygen class ligand and its preparation method. In order to different multiple alkyne substrate through the cascade reaction construct containing three aryl phosphorus oxygen class ligand, the reaction overcomes the lengthy reaction route in the past, the substrate and the harsh reaction conditions, substituted functional group extends the limited and the like, the reaction not only substrate is simple to synthesize, reagent is inexpensive, and has high atom economy, compactly and efficiently to obtain the target molecule, containing three aryl phosphorus oxygen class ligand to transition metal catalytic hydrogen bond activation in the fields of application provides a brand new ways. (by machine translation)

Spirane structure containing dihydronaphthalene ketone derivative and preparation method thereof

The invention provides a spirane structure containing dihydronaphthalene ketone derivative and a preparation method thereof. The preparation method comprises the following steps: 1) reacting malonateand propargyl bromide in an anhydrous acetonitrile solvent by ice water bath through sodium cyanide which is used as a catalyst, and obtaining a compound a; 2) reacting the compound a and a phenyl bromoacetylene compound in the anhydrous acetonitrile solvent under the effects of the catalyst and organic alkali, and obtaining a compound b after the reaction is finished; 3) reacting the compound b and diphenylcyclopropenone in an anhydrous methylbenzene solvent under water-free and oxygen-free condition, and obtaining the spirane structure containing dihydronaphthalene ketone derivative. Compared with the prior art, the method has the advantages that the defects such as long reaction route, rigorous requirements on a substrate and reaction conditions, and limited expansion of substituted functional groups can be overcome; the synthesizing is simple; the cost is low; in addition, the target molecules can be obtained with high atom economy, green and environmental protection property.