1068643-49-1Relevant academic research and scientific papers
New gold(I) and silver(I) complexes of sulfamethoxazole: Synthesis, X-ray structural characterization and microbiological activities of triphenylphosphine(sulfamethoxazolato-N2)gold(I) and (sulfamethoxazolato)silver(I)
Marques, Lenice L.,Manzoni de Oliveira, Gelson,Schulz Lang, Ernesto,Anraku de Campos, Marli Matiko,Soccol Gris, Lara Regina
, p. 1083 - 1087 (2007)
Sulfamethoxazole (SMTZ) reacts with Ph3PAuCl and AgCl in methanol/triethylamine to give [Ph3PAu(SMTZ-1H+)] (SMTZ-1H+ = sulfamethoxazolato anion) (1) and [Ag(SMTZ-1H+)] (2). While the lattice of 1 contains single molecules with linear N-Au-P bonds, compound 2 comprises a two-dimensional polymeric assembly of the deprotonated SMTZ ligand and silver ions, which are coordinated by one oxygen and three nitrogens in a distorted tetrahedral array. The microbiologic activities (Mueller-Hinton broth dilution tests) of 1 and 2 were determined in relation to free sulfamethoxazole.
