New gold(I) and silver(I) complexes of sulfamethoxazole: Synthesis, X-ray structural characterization and microbiological activities of triphenylphosphine(sulfamethoxazolato-N2)gold(I) and (sulfamethoxazolato)silver(I)

Article abstract of DOI:10.1016/j.inoche.2007.06.005

Sulfamethoxazole (SMTZ) reacts with Ph₃PAuCl and AgCl in methanol/triethylamine to give [Ph₃PAu(SMTZ_-1H+)] (SMTZ_-1H+ = sulfamethoxazolato anion) (1) and [Ag(SMTZ_-1H+)] (2). While the lattice of 1 contains single molecules with linear N-Au-P bonds, compound 2 comprises a two-dimensional polymeric assembly of the deprotonated SMTZ ligand and silver ions, which are coordinated by one oxygen and three nitrogens in a distorted tetrahedral array. The microbiologic activities (Mueller-Hinton broth dilution tests) of 1 and 2 were determined in relation to free sulfamethoxazole.