106875-07-4Relevant academic research and scientific papers
2,2,2-trifluoroethanol-promoted access to symmetrically 3,3-disubstituted quinoline-2,4-diones
Abram, Ulrich,Larghi, Enrique L.,Ledesma, Gabriela N.,Morel, Ademir Farias,Schulz-Lang, Ernesto,Selvero, Marcel Manke
, (2020)
The unprecedented use of 2,2,2-trifluoroethanol as reaction solvent provided a facile and convenient access to symmetrically 3,3-disubstitued quinoline-2,4-diones in moderate to excellent yields and high regioselectivity, by reaction of 4-hydroxy-2-quinolones with electrophiles like methyl iodide, as well as benzyl and allyl bromides in the presence of K2CO3. Silver (I) oxide is required to increase the yield of the methylations.
