70254-43-2

Basic information

• Product Name: 2,4-Quinolinediol
• Synonyms: 2,4-QUINOLINEDIOL
• CAS NO: 70254-43-2
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• EINECS: 201-711-0
• Mol File: 70254-43-2.mol
• Article Data: 45

Chemical Properties

• Melting Point: 300℃
• Appearance: /
• CAS DataBase Reference: 2,4-Quinolinediol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Quinolinediol(70254-43-2)
• EPA Substance Registry System: 2,4-Quinolinediol(70254-43-2)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S37/39:
• Hazardous Substances Data: 70254-43-2(Hazardous Substances Data)

Usage

General Description

2,4-Quinolinediol, also known as 2,4-Pyridinediol, is a chemical compound that exists as a white solid at room temperature. It is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 2,4-Quinolinediol has also been studied for its potential applications in the treatment of cancer and as an antioxidant. Additionally, 2,4-Quinolinediol has been found to exhibit antimicrobial properties and has been investigated for its potential use in the development of new antimicrobial agents. However, further research is needed to fully understand its potential benefits and drawbacks in these areas.

InChI:InChI=1/C9H7NO2/c11-8-5-9(12)10-7-4-2-1-3-6(7)8/h1-5H,(H2,10,11,12)

Upstream product

• 606-23-5 1H-indene-1,3(2H)-dione 
• 408508-16-7 (2-formylamino-phenyl)-propiolic acid ethyl ester 
• 141-82-2 malonic acid 
• 62-53-3 aniline 
• 541-16-2 t-butyl malonate 
• 53341-66-5 ethyl 3-oxo-3-(phenylamino)propionate 
• 2033-24-1 cycl-isopropylidene malonate 
• 83-34-1 3-Methylindole 
• 1504-06-9 3-methylindolin-2-one 
• 73776-19-9 1H-4-hydroxy-2-oxoquinoline-3-carboxylic acid methyl ester 
• 105-53-3 diethyl malonate 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 615-43-0 2-iodophenylamine 
• 52670-38-9 2-ethynylaniline 

Downstream Products

• 142071-45-2 N-(5,6-dihydro-2,5-dioxo-2H-pyrano<3,2-c>quinoline-3-yl)benzamide 
• 110216-87-0 4-amino-quinolin-2-ol 
• 14933-24-5 3-bromo-quinoline-2,4-diol 
• 26138-64-7 3-acetyl-2,4-dihydroxyquinoline 
• 177089-62-2 2-amino-5-oxo-4-phenyl-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carbonitrile 
• 824935-58-2 4-(4-methoxyanilino)-1H-quinolin-2-one 
• 6628-93-9 4-anilino-1H-quinolin-2-one 
• 264260-06-2 4-hydroxy-6-nitroquinolin-2(1H)-one 

Relevant articles and documents

Vibrational spectroscopic and molecular docking study of (2E)-N-(4-chloro-2-oxo-1,2-dihydroquinolin-3-yl)-3-phenylprop-2-enamide

FT-IR and FT-Raman spectra of (2E)-N-(4-chloro-2-oxo-1,2-dihydroquinolin-3-yl)-3-phenylprop-2-enamide were recorded and analyzed experimentally and theoretically. The synthesis, 1H NMR and PES scan results are also discussed. Nonlinear optical behavior of the examined molecule was investigated by the determination of first hyperpolarizability. The calculated HOMO and LUMO energies show the chemical activity of the molecule. The stability of the molecule arising from hyper-conjugative interaction and charge delocalization has been analyzed using NBO analysis. From the MEP it is evident that the negative charge covers the carbonyl group and the positive region is over the NH group. The calculated geometrical parameters (SDD) are in agreement with that of similar derivatives. Molecular docking simulations against targets from Mycobacterium tuberculosis are reported and the results suggest that the compound might exhibit inhibitory activity against PknB.

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One-step Synthesis of 3-Unsubstituted 4-Hydroxy-2(1H)-Quinoline

3-Unsubstituted 4-hydroxy-2(1H)-quinolone (DHQ) derivatives were synthesized from aniline derivatives and diethyl malonate at low temperature using AlCl3 as catalyst and Eaton reagent as acidic environment. A reaction mechanism was proposed and elucidated. Different synthetic intermediates are specially prepared or purified and used to understand the reaction and validation mechanism.

Method for preparing 4-hydroxyquinolin-2(1H)-one compound

The invention discloses a method for preparing a 4-hydroxyquinolin-2(1H)-one compound, which comprises the following steps of: reacting 2-ethynylaniline as shown in a formula (1) and carbon dioxide which are used as raw materials in an ionic liquid in the presence of a silver salt catalyst to obtain the 4-hydroxyquinoline-2 (1H)-one compound as shown in a formula (II). The reaction equation is shown in the specification. When the method disclosed by the invention is applied to the reaction for preparing the 4-hydroxyquinolin-2(1H)-one compound, the reaction conditions are relatively mild, the dosage of the silver salt catalyst is small, the separation and purification process of the product is relatively simple, the product yield is high, and the application range of a substrate is wide.

Sequential Oxidative Fragmentation and Skeletal Rearrangement of Peroxides for the Synthesis of Quinazolinone Derivatives

For the first time, the sequential reaction of peroxyoxindole that involves base-promoted oxidative fragmentation to isocyanate formation and primary amine or amino alcohol accelerated skeletal rearrangement to synthesize exo-olefinic-substituted quinazolinone or oxazoloquinazolinone is reported. The advantages of this new reaction include a broad substrate scope and transition-metal-free and room-temperature conditions. The formation of the isocyanate as a key intermediate that accelerates oxidative skeletal rearrangement has been confirmed by trapping experiments and spectroscopic evidence.