106877-43-4

Basic information

• Product Name: Benzene, 1,3-dimethoxy-2-(trifluoromethyl)-
• CAS NO: 106877-43-4
• Molecular Formula: C9H9F3O2
• Molecular Weight: 206.164
• Mol File: 106877-43-4.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Benzene, 1,3-dimethoxy-2-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,3-dimethoxy-2-(trifluoromethyl)-(106877-43-4)
• EPA Substance Registry System: Benzene, 1,3-dimethoxy-2-(trifluoromethyl)-(106877-43-4)

Safety Data

• Hazardous Substances Data: 106877-43-4(Hazardous Substances Data)

Upstream product

• 421-83-0 trifluoromethane sulfonyl chloride 
• 151-10-0 1,3-Dimethoxybenzene 
• 1466-76-8 2-6-dimethoxybenzoic acid 
• 16932-44-8 2-iodo-1,3-dimethoxybenzene 
• 2926-29-6 Langlois reagent 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 41804-89-1 potassium triflinate 
• 75-63-8 Bromotrifluoromethane 
• 23112-96-1 (2,6-dimethoxyphenyl)boronic acid 

Relevant articles and documents

Cathodic C-H Trifluoromethylation of Arenes and Heteroarenes Enabled by an in Situ-Generated Triflyltriethylammonium Complex

While several trifluoromethylation reactions involving the electrochemical generation of CF3 radicals via anodic oxidation have been reported, the alternative cathodic, reductive radical generation has remained elusive. Herein, the first cathodic trifluoromethylation of arenes and heteroarenes is reported. The method is based on the electrochemical reduction of an unstable triflyltriethylammonium complex generated in situ from inexpensive triflyl chloride and triethylamine, which produces CF3 radicals that are trapped by the arenes on the cathode surface.

Metal-Free, Initiator-Free Graphene Oxide-Catalyzed Trifluoromethylation of Arenes

The direct C?H trifluoromethylation of arenes catalyzed by graphene oxide (GO) under safe conditions is described. This strategy is metal-free, initiator-free, safe, and scalable. It employs a readily available CF3 source and the reaction can b

Palladium-Catalyzed Trifluoromethylation of (Hetero)Arenes with CF3Br

The CF3 group is an omnipresent motif found in many pharmaceuticals, agrochemicals, catalysts, materials, and industrial chemicals. Despite well-established trifluoromethylation methodologies, the straightforward and selective introduction of such groups into (hetero)arenes using available and less expensive sources is still a major challenge. In this regard, the selective synthesis of various trifluoromethyl-substituted (hetero)arenes by palladium-catalyzed C-H functionalization is herein reported. This novel methodology proceeds under comparably mild reaction conditions with good regio- and chemoselectivity. As examples, trifluoromethylations of biologically important molecules, such as melatonin, theophylline, caffeine, and pentoxifylline, are showcased.