1069-62-1

Basic information

• Product Name: (2-Acetyl-4-Methylpentyl)triMethylaMMoniuM Iodide
• Synonyms: (2-Acetyl-4-Methylpentyl)triMethylaMMoniuM Iodide;2-acetyl-N,N,N,4-tetraMethylpentan-1-aMiniuM iodide;3-((dimethylamino)methyl)-5-methylhexan-2-one methiodide
• CAS NO: 1069-62-1
• Molecular Formula: C₁₁H₂₄NO*I
• Molecular Weight: 313.21883
• Product Categories: Aliphatics;Amines;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Aliphatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1069-62-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 180-181 °C
• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• CAS DataBase Reference: (2-Acetyl-4-Methylpentyl)triMethylaMMoniuM Iodide(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Acetyl-4-Methylpentyl)triMethylaMMoniuM Iodide(1069-62-1)
• EPA Substance Registry System: (2-Acetyl-4-Methylpentyl)triMethylaMMoniuM Iodide(1069-62-1)

Safety Data

• Hazardous Substances Data: 1069-62-1(Hazardous Substances Data)

Usage

Uses

(2-Acetyl-4-methylpentyl)trimethylammonium Iodide is an impurity of Tetrabenazine (T284000), an antipsychotic.

Upstream product

• 110-12-3 5-Methyl-2-hexanone 
• 86497-40-7 trimethyl-(5-methylhex-2-en-2-yloxy)silane 
• 1522-34-5 ethyl 2-acetyl-4-methylpentanoate 
• 91342-74-4 3-[(dimethylamino)methyl]-5-methylhexan-2-one 
• 74-88-4 methyl iodide 

Downstream Products

• 58-46-8 (3R^*,11bR^*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one 
• 1221885-59-1 deutetrabenazine 
• 1187-87-7 5-methyl-3-methylidenehexan-2-one 
• 89929-27-1 (+/-)-9,10-dihydroxy-3c-isobutyl-(11br)-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-one 
• 89929-27-1 2-Oxo-3-isobutyl-9,10-dihydroxy-1,2,3,4,6,7-hexahydro-11bH-benzochinolizin 
• 718635-93-9 tetrabenazine 
• 1065193-59-0 (2R,3R,11bR)-3-isobutyl-10-methoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2,9-diol 
• 7744-58-3 9-(benzyloxy)-3-isobutyl-10-methoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one 

Relevant articles and documents

Real-Time Monitoring of Solid-Liquid Slurries: Optimized Synthesis of Tetrabenazine

Solid-liquid slurries are vital and increasingly prevalent in the pharmaceutical and chemical industries. Despite the importance of these heterogeneous systems, process control and optimization are fundamentally hindered by a lack of compatible real-time analytical techniques. We present herein an online HPLC monitoring platform enabling access to real-time compositional information on slurries. We demonstrate the system by investigating the heterogeneous synthesis reaction of tetrabenazine. Furthermore, we integrated our online HPLC platform with the orthogonal monitoring techniques of a pH probe and a microscopic imaging probe to provide additional mechanistic insight. These combined insights enable the optimization of tetrabenazine synthesis in terms of reaction time, byproduct formation, and diastereomeric purity of the final product.

BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2

The present invention relates to new benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions thereof, and methods of use thereof.

METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS

The present invention relates to new methods of manufacturing benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), and intermediates thereof.