89929-27-1

Basic information

• Product Name: 9,10-dihydroxy-3-isobutyl-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one
• Synonyms: 9,10-dihydroxy-3-isobutyl-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one;2-Oxo-3-isobutyl-9,10-dihydroxy-1,2,3,4,6,7-hexahydro-11bH-benzochinolizin
• CAS NO: 89929-27-1
• Molecular Formula: C17H23NO3
• Molecular Weight: 289.36942
• EINECS: -0
• Mol File: 89929-27-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 195 °C
• Boiling Point: 483.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.98±0.40(Predicted)
• CAS DataBase Reference: 9,10-dihydroxy-3-isobutyl-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9,10-dihydroxy-3-isobutyl-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one(89929-27-1)
• EPA Substance Registry System: 9,10-dihydroxy-3-isobutyl-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one(89929-27-1)

Safety Data

• Hazardous Substances Data: 89929-27-1(Hazardous Substances Data)

Usage

Description

9,10-dihydroxy-3-isobutyl-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one is a complex organic compound belonging to the class of isoquinoline alkaloids. It features a pyridoisoquinoline skeleton with a dihydroxy group at the 9th and 10th positions and an isobutyl group at the 3rd position. 9,10-dihydroxy-3-isobutyl-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one is synthesized from natural sources and exhibits a range of pharmacological activities, such as anticancer, antimicrobial, and anti-inflammatory properties. Its potential therapeutic applications in treating various diseases and disorders make it a significant compound in medicinal chemistry research.

Uses

Used in Pharmaceutical Industry:
9,10-dihydroxy-3-isobutyl-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one is used as a pharmaceutical agent for its anticancer properties. It targets various types of cancer cells and can be utilized in combination with conventional chemotherapeutic drugs to enhance their efficacy and overcome drug resistance.
Used in Antimicrobial Applications:
In the field of antimicrobial research, 9,10-dihydroxy-3-isobutyl-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one serves as an antimicrobial agent, effective against a range of bacteria and other pathogens. Its ability to inhibit microbial growth makes it a promising candidate for the development of new antibiotics and antifungal agents.
Used in Anti-inflammatory Applications:
9,10-dihydroxy-3-isobutyl-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one is employed as an anti-inflammatory agent, demonstrating potential in reducing inflammation and alleviating symptoms associated with various inflammatory conditions. Its anti-inflammatory properties make it a valuable compound for the development of new therapeutics to treat chronic inflammatory diseases.

Upstream product

• 1069-62-1 trimethyl[2-(2-methylpropyl)-3-oxobutyl]azanium iodide 
• 1187-87-7 5-methyl-3-methylidenehexan-2-one 
• 58-46-8 (3R^*,11bR^*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one 

Downstream Products

• 58-46-8 (3R^*,11bR^*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one 
• 1221885-59-1 deutetrabenazine 
• 718635-93-9 tetrabenazine 

Relevant articles and documents

Novel Process for Preparation of Tetrabenazine and Deutetrabenazine

A novel process for the synthesis of tetrabenazine (1) and deutetrabenazine (2), two well-known drugs used for the treatment of chorea associated with Huntington's disease, has been developed. All of the reaction parameters were optimized through a series of reactions and by using Design of Experiment techniques. The newly developed methods are industrially scalable and employ cheap, commercially available raw materials and hence are highly efficient. The added advantage is that the developed processes evade the use of genotoxic alkylating agents and therefore could be considered as safe and viable alternatives to the existing methods.