106900-09-8Relevant academic research and scientific papers
Assessment of elementary derivatives of 1,5-benzodiazepine as anticancer agents with synergy potential
Gawandi, Sinthiya J.,Joshi, Shrinivas,Pissurlenkar, Raghuvir R.,Shingade, Sunil,desai, Vidya G.
, (2021/12/10)
Herein, we designed and synthesized 1,5-benzodiazepines as a lead molecule for anticancer activity and as potent synergistic activity with drug Methotrexate. Working under the framework of green chemistry principles, series of 1,5-benzodiazepine derivativ
Method for preparing benzodinitrogen compound by using gold complex
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Paragraph 0057-0064, (2021/07/17)
The invention relates to a method for preparing a benzodinitrogen compound by using a gold complex, which comprises the following step of: reacting an o-phenylenediamine compound and alkyne as raw materials with a gold complex containing a diphosphine ort
A green and sustainable approach for the synthesis of 1,5-benzodiazepines and spirooxindoles in one-pot using a MIL-101(Cr) metal-organic framework as a reusable catalyst
Anal, Jasha Momo H.,Gupta, Ajay,Jamatia, Ramen,Pal, Amarta Kumar,Sarkar, Fillip Kumar
, p. 19553 - 19564 (2021/11/09)
Metal-organic framework MIL-101(Cr) has been efficiently utilized for the synthesis of biologically relevant heterocycles such as 1,5-benzodiazepines and spirooxindoles in one-pot. MIL-101(Cr) was prepared via a solvothermal method and characterized by FT
Formation of benzodiazepines and pyrazinylquinoxalines from aromatic and heteroaromatic ketones via deoximation
Song,Bae,Lee,Cho,Jung
, p. 1676 - 1680 (2020/07/30)
The report stated that the treatment of o-phenylenediamine with acetone dicarboxylic acid, acetone and acetophenone afforded 2,4,4- trimethyl-3H-5-hydro-1,5-benzodiazepine. However, direct reactions of o-phenylenediamine with oximes (acetone oxime, acetophenone oxime, and benzophenone oxime) as ketone equivalents did not occur. In the course of present investigations, it is found that dichloroamineT can be an efficient reagent for the conversion of oximes into the corresponding carbonyl compounds. As a part of a research program related to the synthetic study of pharmacologically interesting benzodiazepine compounds, herein the synthesis of 1H-1,5-benzodiazepine derivatives from heteroaromatic ketones and acetone equivalents obtained using dichloroamine-T. On the other hand, when diamine (1,2- phenylene diamine or 1,2-naphthalene diamine) with heterocyclic ketone (acetyl pyridine or acetyl pyrazines) in the presenece of conc. HCl and SiO2was refluxed, quinoxaline derivatives as yellow crystalline solids were isolated in high yields.
Gold(I)-catalyzed synthesis of 1,5-benzodiazepines directly from o-phenylenediamines and alkynes
Qian, Jianqiang,Liu, Yunkui,Cui, Jianhai,Xu, Zhenyuan
experimental part, p. 4484 - 4490 (2012/06/18)
A unique gold(I)-catalyzed highly atom-economic synthesis of 1,5-benzodiazepines directly from o-phenylenediamines and alkynes has been achieved for the first time.
NBS as an efficient catalyst for the synthesis of 1,5-benzodiazepine derivatives under mild conditions
Kuo, Chun-Wei,More, Shivaji V.,Yao, Ching-Fa
, p. 8523 - 8528 (2007/10/03)
Various biologically important 1,5-benzodiazepine derivatives were efficiently synthesized in excellent yields using catalytic amounts of NBS (10 mol %). This inexpensive, nontoxic, and readily available catalyst efficiently catalyzes the condensation of
DERIVATIVES OF 2,3-DIHYDRO-1H-1,5-BENZODIAZEPINE BASED ON SUBSTITUTED 1,2-PHENYLENEDIAMINES AND ACETYLARENES
Orlov, V. D.,Desenko, S. M.
, p. 1377 - 1381 (2007/10/02)
Derivatives of 2,3-dihydro-1H-1,5-benzodiazepine were obtained by the reaction of 4-chloro-, 4-bromo- 3,5-dichloro, and 4-cyano-substituted ortho-phenyl-enediamines with 4-R-acetophenones in the presence of concentrated sulfuric acid.Electronwithdrawing g
