1069070-10-5

Basic information

• Product Name: N-(tert-butyldiphenylsilyl)-S,S-dimethylsulfoximine
• Synonyms: N-(tert-butyldiphenylsilyl)-S,S-dimethylsulfoximine
• CAS NO: 1069070-10-5
• Molecular Weight: 331.554
• Mol File: 1069070-10-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(tert-butyldiphenylsilyl)-S,S-dimethylsulfoximine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-butyldiphenylsilyl)-S,S-dimethylsulfoximine(1069070-10-5)
• EPA Substance Registry System: N-(tert-butyldiphenylsilyl)-S,S-dimethylsulfoximine(1069070-10-5)

Safety Data

• Hazardous Substances Data: 1069070-10-5(Hazardous Substances Data)

Upstream product

• 1520-31-6 dimethylsulfoximine 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 1069070-32-1 (S)-N-(tert-butyldiphenylsilyl) (2-bromophenyl)ethyl methyl sulfoximine 
• 1356395-38-4 N-(tert-butyldiphenylsilyl) (2-bromo-3-pyridyl)ethyl methyl sulfoximine 
• 1356395-35-1 N-(tert-butyldiphenylsilyl) (2-bromo-4-methoxyphenyl)ethyl methyl sulfoximine 
• 1373210-34-4 N-tert-butyldiphenylsilyl methyl n-tridecyl sulfoximine 
• 1069070-17-2 (S)-N-tert-butyldiphenylsilyl methyl trimethylsilylmethyl sulfoximine 

Relevant articles and documents

Palladium-Catalyzed Direct α-Arylation of p -Methoxybenzyl-Protected S, S -Dimethylsulfoximine

Sulfoximines have recently gained considerable recognition as an important structural motif in the life sciences. This is especially true for (hetero)aryl-substituted S,S-dimethylsulfoximine derivatives, such as the marketed insecticide sulfoxaflor, as well as the clinical candidates PTEFb inhibitor BAY 1143572 and ATR inhibitor AZD 6738 for the treatment of cancer. Herein, the first palladium-catalyzed direct α-arylation of p-methoxybenzyl-protected S,S-dimethylsulfoximine using readily available (hetero)aryl bromides is reported. This new method provides a safe, short, and efficient approach to (hetero)aryl-substituted S,S-dimethylsulfoximine derivatives, an important class of bioactive compounds, demonstrated by application of this methodology to an improved synthesis of PTEFb inhibitor BAY 1143572.