1520-31-6

Usage

Uses

Used in Chemical Synthesis:
S,S-dimethyl sulfoximine is used as a reactant for the synthesis of N-?sulfenyl sulfoximines derivatives. Its unique structure enables the formation of these derivatives, which can be further utilized in various applications, such as pharmaceuticals and materials science.
Used in Organic Chemistry:
S,S-dimethyl sulfoximine is used as a reactant for N-?thioetherification of NH-?sulfoximines. This reaction is important in the development of new compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C2H7NOS/c1-5(2,3)4/h3H,1-2H3

Upstream product

• 13904-95-5 S,S-dimethylsulfodiimide 
• 67-66-3 chloroform 
• 7664-93-9 sulfuric acid 
• 67-68-5 dimethyl sulfoxide 
• 21865-94-1 S,S-dimethyl-N-phthalimidosulfoximine 
• 62995-07-7 Benzyl (dimethyl(oxo)-λ⁶-sulfaneylidene)carbamate 
• 748142-64-5 N-acetyl-S,S-dimethylsulfoximine 
• 75-18-3 dimethylsulfide 
• 22236-45-9 S,S-dimethyl-N-(4-tolylsulfonyl)sulfoximine 

Downstream Products

• 1520-18-9 C₁₀H₁₄N₂O₂S 
• 1520-02-1 C₉H₁₁ClN₂O₂S 
• 1520-00-9 C₉H₁₁ClN₂O₂S 
• 1520-03-2 C₉H₁₀Cl₂N₂O₂S 
• 1520-08-7 C₉H₁₁N₃O₄S 
• 1520-10-1 S,S-dimethyl-N-[(4-nitrophenyl)carbamoyl]sulphoximide 
• 1519-99-9 C₉H₁₂N₂O₂S 
• 1520-04-3 C₉H₁₀Cl₂N₂O₂S 
• 1520-01-0 C₉H₁₁ClN₂O₂S 
• 1520-14-5 C₉H₁₂N₂O₄S₂ 
• 1520-16-7 C₁₃H₂₀N₄O₄S₂ 
• 88317-04-8 C₁₀H₁₄N₂OS 
• 88317-07-1 N-(dimethyl(oxo)-λ6-sulfanylidene)-N'-(p-tolyl)benzimidamide 
• 56158-11-3 methyl 4-((dimethyl(oxo)-λ⁶-sulfaneylidene)amino)benzoate 

Relevant academic research and scientific papers

One-Pot Synthesis of N-Iodo Sulfoximines from Sulfides

This is the first report on the synthesis and characterization of N-iodo sulfoximines. The synthesis was designed as a room temperature one-pot cascade reaction from readily available sulfides as starting compounds, converted into sulfoximines by reaction with ammonium carbonate and (diacetoxyiodo)benzene, followed by iodination with N-iodosuccinimide or iodine in situ, in up to 90% isolated yields, also at a multigram scale. Iodination of aryls with N-iodo sulfoximines, oxidation, and conversion to N-SCF3 congeners have been demonstrated.

Nickel-Catalyzed N-Arylation of NH-Sulfoximines with Aryl Halides via Paired Electrolysis

A novel strategy for the N-arylation of NH-sulfoximines has been developed by merging nickel catalysis and electrochemistry (in an undivided cell), thereby providing a practical method for the construction of sulfoximine derivatives. Paired electrolysis is employed in this protocol, so a sacrificial anode is not required. Owing to the mild reaction conditions, excellent functional group tolerance and yield are achieved. A preliminary mechanistic study indicates that the anodic oxidation of a NiII species is crucial to promote the reductive elimination of a C?N bond from the resulting NiIII species at room temperature.

BIARYL DERIVATIVE, PREPARATION METHOD THEREOF AND PHARMACEUTICAL APPLICATION THEREOF

Disclosed are a biaryl derivative having a structure represented by Formula (I) and inhibitory activity against PD-1/PD-L1 interaction, a preparation method thereof, and a pharmaceutical application thereof. The series of compounds of the present inventio

HETEROCYCLIC INHIBITORS OF ATR KINASE

The present disclosure relates to heterocyclic compounds and methods which inhibit ATR kinase to treat or prevent cancer.

I2/PhI(OAc)2 Copromoted Amination Reaction: Synthesis of α-Dicarbonylsulfoximine Derivatives by Incorporating an Intact Dimethyl Sulfoxide

An I2/PhI(OAc)2 copromoted strategy using dimethyl sulfoxide as an "S/C2/O" source for preparing α-dicarbonylsulfoximine derivatives is reported. This process involves oxidative coupling to construct a C-N bond and electrophilic amin

HETEROCYCLIC INHIBITORS OF ATR KINASE

The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

PYRROLO[2,3-C]PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE

Disclosed are a pyrrolo[2,3-c]pyridine derivative, a preparation method therefor, and use thereof in medicine. Specifically, disclosed are a pyrrolo[2,3-c]pyridine derivative as represented by general formula (1), a preparation method therefor, a pharmaceutical composition comprising the derivative, as well as use thereof as a BRD4 inhibitor in the treatment of related diseases such as cancers, inflammations, chronic liver diseases, diabetes, cardiovascular diseases and AIDS, each substituent in general formula (I) being same as defined in the description.

SULFOXIMINE, SULFONIMIDAMIDE, SULFONDIIMINE AND DIIMIDOSULFONAMIDE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2, 3-DIOXYGENASE

Provided are certain IDO inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Copper-catalyzed oxidative decarboxylative coupling of α-keto acids and sulfoximines

A copper-catalyzed oxidative decarboxylative coupling of α-keto acids with NH-sulfoximines has been developed. With CuBr as the catalyst and K2S2O8 as the oxidant, this reaction enables the formation of a C-N bond and gives N-aroylsulfoximine products in moderate to excellent yields. The reaction mechanism is likely to involve the generation of a reactive aroyl radical intermediate.

Metal-Free, Phosphonium Salt-Mediated Sulfoximination of Azine N-Oxides: Approach for the Synthesis of N-Azine Sulfoximines

Herein, we report a simple and metal-free method for the synthesis of N-azine sulfoximines by the nucleophilic substitution of azine N-oxides with NH-sulfoximines. The present method works at room temperature with wide functional group compatibility and gives several unprecedented N-azine sulfoximines. The reaction conditions were also found suitable with enantiopure substrates and furnished products without any racemization. It also finds an application in the sulfoximination of azine-based functional molecules such as 2,2′-bipyridine, 1,10-phenanthroline, and quinine.