1069084-84-9Relevant academic research and scientific papers
Identification of ring-fused pyrazolo pyridin-2-ones as novel poly(ADP-ribose)polymerase-1 inhibitors
Moree, Wilna J.,Goldman, Phyllis,Demaggio, Anthony J.,Christenson, Erik,Herendeen, Dan,Eksterowicz, John,Kesicki, Edward A.,McElligott, David L.,Beaton, Graham
scheme or table, p. 5126 - 5129 (2009/05/07)
A novel class of PARP-1 inhibitors was identified containing a non-aromatic heterocycle or carbocycle fused to a pyrazolo pyridin-2-one. Compounds displayed low nanomolar binding activity in the PARP-1 binding assay and submicromolar activity in a cell based chemosensitization assay.
