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1069085-40-0

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1069085-40-0 Usage

General Description

1-Benzyl-2-(trifluoroMethyl)-4,5-dihydro-1H-iMidazole, also known as flumazenil, is a potent antagonist of the central benzodiazepine receptor. It is used in the reversal of the sedative effects of benzodiazepines in cases of overdose or in surgical and diagnostic procedures. Flumazenil works by competitively inhibiting the binding of benzodiazepines to their receptors in the central nervous system, effectively reversing their sedative and hypnotic effects. It is commonly administered intravenously and has a relatively short half-life, making it an effective and safe option for the rapid reversal of benzodiazepine effects. Flumazenil is also being investigated for potential therapeutic uses in the treatment of benzodiazepine dependence and withdrawal.

Check Digit Verification of cas no

The CAS Registry Mumber 1069085-40-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,9,0,8 and 5 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1069085-40:
(9*1)+(8*0)+(7*6)+(6*9)+(5*0)+(4*8)+(3*5)+(2*4)+(1*0)=160
160 % 10 = 0
So 1069085-40-0 is a valid CAS Registry Number.

1069085-40-0Downstream Products

1069085-40-0Relevant articles and documents

A facile one-pot synthesis of 2-fluoroalkyl 1,3-imidazolines and 1,3-oxazolines through imidoyl halide intermediates

Jiang, Haizhen,Sun, Lan,Yuan, Shijie,Lu, Wenjun,Wan, Wen,Zhu, Shizheng,Hao, Jian

experimental part, p. 2858 - 2863 (2012/05/05)

A facile one-pot procedure has been developed for the synthesis of 1,3-imidazolines and 1,3-oxazolines bearing fluorinated alkyl groups at the 2-position. The reaction involves the condensation of N-monosubstituted ethane-1,2-diamines or 2-aminoethanols with a fluorinated carboxylic acid in the presence of PPh3/CX4. The proposed mechanism is that the amide intermediates were initially formed, and then converted to the imidoyl halide intermediates in the presence of PPh3/CX4, followed by rapid intramolecular cyclization to 1,3-diazoline products. This protocol allows for the synthesis of 2-bromodifluoromethyl-1,3-imidazoline, a useful CF2Br-heterocyclic building block, which can be used for the synthesis of gem-difluoromethylene linked compounds.

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