1069085-50-2 Usage
Uses
Used in Pharmaceutical Industry:
2-(DifluoroMethyl)-1-phenyl-4,5-dihydro-1H-iMidazole is used as a kinase inhibitor for the treatment of various diseases, particularly cancer. It functions by inhibiting the activities of specific kinases, thereby preventing the growth and spread of cancer cells.
Used in Cancer Treatment:
2-(DifluoroMethyl)-1-phenyl-4,5-dihydro-1H-iMidazole is used as a potential cancer treatment, especially in combination with other drugs. It is currently under investigation in clinical trials for the treatment of various types of cancers, making it a promising candidate for the development of new cancer therapies.
Used in Clinical Trials:
2-(DifluoroMethyl)-1-phenyl-4,5-dihydro-1H-iMidazole is used in clinical trials to evaluate its efficacy and safety in the treatment of various cancers. These trials aim to determine the optimal dosage, administration methods, and potential side effects, as well as to assess its synergistic effects when combined with other cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 1069085-50-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,9,0,8 and 5 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1069085-50:
(9*1)+(8*0)+(7*6)+(6*9)+(5*0)+(4*8)+(3*5)+(2*5)+(1*0)=162
162 % 10 = 2
So 1069085-50-2 is a valid CAS Registry Number.
1069085-50-2Relevant academic research and scientific papers
A facile one-pot synthesis of 2-fluoroalkyl 1,3-imidazolines and 1,3-oxazolines through imidoyl halide intermediates
Jiang, Haizhen,Sun, Lan,Yuan, Shijie,Lu, Wenjun,Wan, Wen,Zhu, Shizheng,Hao, Jian
supporting information; experimental part, p. 2858 - 2863 (2012/05/05)
A facile one-pot procedure has been developed for the synthesis of 1,3-imidazolines and 1,3-oxazolines bearing fluorinated alkyl groups at the 2-position. The reaction involves the condensation of N-monosubstituted ethane-1,2-diamines or 2-aminoethanols with a fluorinated carboxylic acid in the presence of PPh3/CX4. The proposed mechanism is that the amide intermediates were initially formed, and then converted to the imidoyl halide intermediates in the presence of PPh3/CX4, followed by rapid intramolecular cyclization to 1,3-diazoline products. This protocol allows for the synthesis of 2-bromodifluoromethyl-1,3-imidazoline, a useful CF2Br-heterocyclic building block, which can be used for the synthesis of gem-difluoromethylene linked compounds.
