1069085-50-2 Usage
General Description
2-(DifluoroMethyl)-1-phenyl-4,5-dihydro-1H-iMidazole, also known as Fimasertib, is a chemical compound with the molecular formula C10H10F2N2. It belongs to the class of imidazole derivatives and is used in the pharmaceutical industry as a kinase inhibitor for the treatment of various diseases. Fimasertib has shown potential for the treatment of cancer, particularly in combination with other drugs. It works by inhibiting the activities of specific kinases, thereby preventing the growth and spread of cancer cells. Fimasertib is currently under investigation in clinical trials for the treatment of various types of cancers, making it a promising candidate for the development of new cancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 1069085-50-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,9,0,8 and 5 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1069085-50:
(9*1)+(8*0)+(7*6)+(6*9)+(5*0)+(4*8)+(3*5)+(2*5)+(1*0)=162
162 % 10 = 2
So 1069085-50-2 is a valid CAS Registry Number.
1069085-50-2Relevant articles and documents
A facile one-pot synthesis of 2-fluoroalkyl 1,3-imidazolines and 1,3-oxazolines through imidoyl halide intermediates
Jiang, Haizhen,Sun, Lan,Yuan, Shijie,Lu, Wenjun,Wan, Wen,Zhu, Shizheng,Hao, Jian
supporting information; experimental part, p. 2858 - 2863 (2012/05/05)
A facile one-pot procedure has been developed for the synthesis of 1,3-imidazolines and 1,3-oxazolines bearing fluorinated alkyl groups at the 2-position. The reaction involves the condensation of N-monosubstituted ethane-1,2-diamines or 2-aminoethanols with a fluorinated carboxylic acid in the presence of PPh3/CX4. The proposed mechanism is that the amide intermediates were initially formed, and then converted to the imidoyl halide intermediates in the presence of PPh3/CX4, followed by rapid intramolecular cyclization to 1,3-diazoline products. This protocol allows for the synthesis of 2-bromodifluoromethyl-1,3-imidazoline, a useful CF2Br-heterocyclic building block, which can be used for the synthesis of gem-difluoromethylene linked compounds.
