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381-73-7 Usage

Chemical Properties

clear colorless to light brown liquid


Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine.


ChEBI: A monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by fluorines.

Flammability and Explosibility


Purification Methods

Purify the acid by distilling over P2O5. The acid chloride is a fuming liquid b 25o/atm, and the amide has b 108.6o/35mm, m 52o (from *C6H6), and the anilide has b 90o/1mm, 114o/5mm, m 58o [Henne & Pelley J Am Chem Soc 74 1426 1952, Coffman et al. J Org Chem 14 749 1949, NMR: Meyer et al. J Am Chem Soc 75 4567 1953, pK: Wegscheider Z Phys Chem 69 614 1909]. [Beilstein 2 IV 455.]

Check Digit Verification of cas no

The CAS Registry Mumber 381-73-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,8 and 1 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 381-73:
67 % 10 = 7
So 381-73-7 is a valid CAS Registry Number.

381-73-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (D1423)  Difluoroacetic Acid  >97.0%(T)

  • 381-73-7

  • 5g

  • 490.00CNY

  • Detail
  • TCI America

  • (D1423)  Difluoroacetic Acid  >97.0%(T)

  • 381-73-7

  • 25g

  • 1,190.00CNY

  • Detail
  • Alfa Aesar

  • (A12787)  Difluoroacetic acid, 98%   

  • 381-73-7

  • 5g

  • 566.0CNY

  • Detail
  • Alfa Aesar

  • (A12787)  Difluoroacetic acid, 98%   

  • 381-73-7

  • 25g

  • 2594.0CNY

  • Detail
  • Aldrich

  • (142859)  Difluoroaceticacid  98%

  • 381-73-7

  • 142859-5G

  • 709.02CNY

  • Detail
  • Aldrich

  • (142859)  Difluoroaceticacid  98%

  • 381-73-7

  • 142859-25G

  • 2,540.07CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017


1.1 GHS Product identifier

Product name difluoroacetic acid

1.2 Other means of identification

Product number -
Other names Acetic acid, difluoro-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:381-73-7 SDS

381-73-7Relevant articles and documents

Preparation and properties of two novel selenoacetic acids: HCF 2C(O)SeH and ClCF2C(O)SeH

Gomez Castano, Jovanny A.,Romano, Rosana M.,Beckers, Helmut,Willner, Helge,Della Vedova, Carlos O.

, p. 2608 - 2615 (2012)

The novel selenocarboxylic Se-acids, HCF2C(O)SeH and ClCF 2C(O)SeH, were prepared by treating the corresponding carboxylic acids with Woollins' reagent. The boiling points were extrapolated from the vapor pressure curves to be 364 and 359 K for HCF2C(O)SeH and ClCF2C(O)SeH, respectively. Both compounds are unstable at ambient temperatures and decompose to the corresponding seleno anhydrides and release of H2Se. Hydrolysis results in formation of the carboxylic acids and hydrogen selenide, while diselenides presumably are obtained by oxidation. The conformational properties of these acids were studied by vibrational spectroscopy in combination with ab initio and DFT methods. IR vapor-phase spectra, Raman spectra of the neat liquids, and IR spectra of the Ar-matrix-isolated compounds deposited at two different nozzle temperatures were interpreted in terms of quenching conformational equilibria. The most stable structure of both acids was found to be syn-gauche in equilibrium with a second anti-syn form in HCF2C(O)SeH and with another two conformers, anti-gauche and anti-syn, in ClCF2C(O)SeH.

Synthetic method of difluoroacetic acid


Paragraph 0021-0039, (2021/03/24)

The invention relates to a synthetic method of difluoroacetic acid, belonging to the technical field of organic fluorine chemical industry. According to the synthetic method of difluoroacetic acid, 1,1-difluoroethane (R152a) and hydrogen peroxide are taken as raw materials, difluoroacetic acid is prepared in one step, unreacted 1,1-difluoroethane (R152a) is recycled after recovery, the selectivityand conversion rate of the target product are high, and the synthetic method is non-corrosive to equipment, safe and environment-friendly. A catalyst used in the invention is a solid acid catalyst, has high catalytic efficiency, can be repeatedly used, can be easily separated from a reaction system after the reaction is finished, and is particularly suitable for preparing difluoroacetic acid from1,1-difluoroethane (R152a) and hydrogen peroxide. Raw materials adopted in the invention are common reagents and easily available and cheap; and reaction conditions are mild, and a reaction process is easy to control. The prepared difluoroacetic acid product has higher yield and is suitable for industrial production.

Preparation method of difluoroacetic acid


Paragraph 0020-0025, (2019/04/10)

The invention relates to a preparation method of difluoroacetic acid, and belongs to the technical field of fluorine chemical engineering. According to the preparation method of the difluoroacetic acid, KMnO4/C solid catalysts are added into a fixed bed reaction kettle; nitrogen gas is introduced to perform replacement on the air in the reaction kettle; the temperature is raised to a fixed temperature; then, hydrogen peroxide and 2-chlorine-1,1-difluoroethane are introduced by a voltage stabilizing pump to perform contact reaction; after a product is separated, the product of difluoroacetic acid is finally obtained. The preparation method of the difluoroacetic acid has the advantages that the process is simple; the flow process is short; the technical flow process is simplified; the energyconsumption is greatly reduced; the method is suitable for industrialized production; the used raw materials are all common reagents, the resources of the materials are wide, and the price is low; the reaction process can be easily controlled; the obtained difluoroacetic acid product has high yield and has wide application and popularization values.

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