381-73-7Relevant articles and documents
Preparation and properties of two novel selenoacetic acids: HCF 2C(O)SeH and ClCF2C(O)SeH
Gomez Castano, Jovanny A.,Romano, Rosana M.,Beckers, Helmut,Willner, Helge,Della Vedova, Carlos O.
, p. 2608 - 2615 (2012)
The novel selenocarboxylic Se-acids, HCF2C(O)SeH and ClCF 2C(O)SeH, were prepared by treating the corresponding carboxylic acids with Woollins' reagent. The boiling points were extrapolated from the vapor pressure curves to be 364 and 359 K for HCF2C(O)SeH and ClCF2C(O)SeH, respectively. Both compounds are unstable at ambient temperatures and decompose to the corresponding seleno anhydrides and release of H2Se. Hydrolysis results in formation of the carboxylic acids and hydrogen selenide, while diselenides presumably are obtained by oxidation. The conformational properties of these acids were studied by vibrational spectroscopy in combination with ab initio and DFT methods. IR vapor-phase spectra, Raman spectra of the neat liquids, and IR spectra of the Ar-matrix-isolated compounds deposited at two different nozzle temperatures were interpreted in terms of quenching conformational equilibria. The most stable structure of both acids was found to be syn-gauche in equilibrium with a second anti-syn form in HCF2C(O)SeH and with another two conformers, anti-gauche and anti-syn, in ClCF2C(O)SeH.
Synthesis process of difluoroacetic acid
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Paragraph 0022; 0024-0025; 0027-0028; 0030-0031; 0033; ..., (2021/11/14)
The synthesis process comprises the following steps: adding dialkylamines in a dry reaction vessel, first organic solvent and volume concentration of 10 - 40% alkali liquor, dropwise adding dichloroacetyl chloride, carrying out heat preservation stirring after dropwise addition, organic subtraction pressure desolventizing and concentrating to obtain dichloroacetyl dialkylamine. Potassium fluoride, second organic solvent and dichloroacetyl dialkylamine were added to another reaction vessel, and the molar ratio @timetime@ and thermal insulation of the potassium fluoride, the solvent diethylene glycol and the dichloroacetyl 3:5:1 dialkylamine is @. The equimolar difluoroacetyl dialkylamine and the volume concentration were mixed with 10 - 30% lye, reflux was 4 - 10h, dichloroacetyl dialkylamine was recovered by distillation, and the bottoms of the bottoms were adjusted pH=1 with hydrochloric acid and distilled again to give difluoro acetic acid.
Preparation method of difluoroacetic acid
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Paragraph 0020-0025, (2019/04/10)
The invention relates to a preparation method of difluoroacetic acid, and belongs to the technical field of fluorine chemical engineering. According to the preparation method of the difluoroacetic acid, KMnO4/C solid catalysts are added into a fixed bed reaction kettle; nitrogen gas is introduced to perform replacement on the air in the reaction kettle; the temperature is raised to a fixed temperature; then, hydrogen peroxide and 2-chlorine-1,1-difluoroethane are introduced by a voltage stabilizing pump to perform contact reaction; after a product is separated, the product of difluoroacetic acid is finally obtained. The preparation method of the difluoroacetic acid has the advantages that the process is simple; the flow process is short; the technical flow process is simplified; the energyconsumption is greatly reduced; the method is suitable for industrialized production; the used raw materials are all common reagents, the resources of the materials are wide, and the price is low; the reaction process can be easily controlled; the obtained difluoroacetic acid product has high yield and has wide application and popularization values.
