1069111-61-0Relevant academic research and scientific papers
Nickel-Catalyzed Asymmetric Hydrocyanation of Allenes
Long, Jinguo,Gao, Jihui,Fang, Xianjie
, p. 376 - 380 (2020)
The first catalytic enantioselective hydrocyanation of allenes catalyzed by a (R,R)-Ph-BPE-Ni(0) complex catalyst has been accomplished. Numerous optically active allylic nitriles were obtained in good yield with excellent enantioselectivities (up to 98%
Nickel-Catalyzed Isomerization/Allylic Cyanation of Alkenyl Alcohols
Ding, Ying,Long, Jinguo,Sun, Feilong,Fang, Xianjie
supporting information, p. 6073 - 6078 (2021/08/16)
Herein reported is a nickel-catalyzed isomerization/allylic cyanation of alkenyl alcohols, which complements current methods for the allylic substitution reactions. The specific diphosphite ligand and methanol as the solvent are crucial for the success for this transformation. A gram-scale regioconvergent experiment and formal synthesis of quebrachamine demonstrate the high potential of this methodology.
Nickel-catalysed novel β,γ-unsaturated nitrile synthesis
Tang, Shan,Liu, Chao,Lei, Aiwen
supporting information, p. 2442 - 2444 (2013/04/10)
Through a nickel-catalysed Heck-type reaction, a direct coupling of alkenes with α-cyano alkyl bromides was achieved. This procedure provides a novel way for the synthesis of β,γ-unsaturated nitriles.
General, stereoselective synthesis of (Z)-β,γ-unsaturated nitriles promoted by samarium diiodide
Concellon, Jose M.,Rodriguez-Solla, Humberto,Simal, Carmen,Santos, David,Paz, Nieves R.
supporting information; scheme or table, p. 4549 - 4552 (2009/05/11)
(Chemical Equation Presented) A method to obtain (Z)-β,γ- unsaturated nitriles in high or good yields and with moderate or high stereoselectivity is described. The products were achieved through the photoinduced metalation of 3-acetoxy-4-chloronitriles with Sml2. The starting compounds were readily prepared, and a mechanism is proposed to explain this stereoselective β-elimination reaction.
