1069130-59-1Relevant academic research and scientific papers
Regioselective synthesis of rare 3-halomethylphenols based on formal [3+3] cyclizations of 1,3-bis(trimethylsilyloxy)-1,3-butadienes
Lubbe, Mathias,Mamat, Constantin,Langer, Peter
experimental part, p. 1684 - 1686 (2009/05/30)
The cyclization of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with halo-substituted enones afforded 3-difluorochloromethyl-, 3-difluorobromomethyl- , 3-dichloromethyl-, and 3-trichloromethylphenols with very good regioselectivity. The hydrolysis of the dichloromethyl group gave functionalized 3-formylphenols, which are not readily available by other methods. Thieme Stuttgart.
