106928-30-7Relevant academic research and scientific papers
Stereodivergent Total Synthesis of Hapalindoles, Fischerindoles, Hapalonamide H, and Ambiguine H Alkaloids by Developing a Biomimetic, Redox-Neutral, Cascade Prins-Type Cyclization
Sahu, Samrat,Das, Beauty,Maji, Modhu Sudan
, p. 6485 - 6489 (2018/10/24)
A stereoselective, redox-neutral, Br?nsted acid-catalyzed cascade Prins-type cyclization between indole and aldehyde is described to access several structurally diverse indole terpenoid scaffolds in a single step. Applying this concept, stereodivergent to
Total synthesis of hapalindole-type natural products
Lu, Zhaohong,Yang, Ming,Chen, Pengxi,Xiong, Xiaochun,Li, Ang
, p. 13840 - 13844 (2015/03/13)
A unified and bioinspired oxidative cyclization strategy was used in the first total syntheses of naturally occurring 12-epi-hapalindole Q isonitrile, hapalonamide H, deschloro 12-epi-fischerindole I nitrile, and deschloro 12-epi-fischerindole W nitrile, as well as the structural revision of the latter. Hapalindoles H and Q were also synthesized.
Total synthesis of hapalindoles J and U
Rafferty, Ryan J.,Williams, Robert M.
experimental part, p. 519 - 524 (2012/03/26)
The total synthesis of d,l-hapalindoles J and U has been accomplished. Hapalindole J was prepared in 11% overall yield over 11 synthetic steps and hapalindole U was prepared in 25% overall yield over 13 synthetic steps from commercially available materials. The route employs a novel silyl ether-based strategy for accessing the 6:5:6:6 ring system of the hapalindoles rapidly and in good yields.
Synthetic studies of marine alkaloids hapalindoles. Part 3. Total synthesis of (±)-hapalindoles H and U
Muratake, Hideaki,Kumagami, Harumi,Natsume, Mitsutaka
, p. 6351 - 6360 (2007/10/02)
A total, synthesis of marine indole alkaloids (±) -hapalindoles H (1) and U (2) was achieved from the previously described compound 7 by way of 13, 21, and 26 for U (2), and 33 and 32 for H (1).
