131572-81-1Relevant articles and documents
Total synthesis of hapalindoles J and U
Rafferty, Ryan J.,Williams, Robert M.
experimental part, p. 519 - 524 (2012/03/26)
The total synthesis of d,l-hapalindoles J and U has been accomplished. Hapalindole J was prepared in 11% overall yield over 11 synthetic steps and hapalindole U was prepared in 25% overall yield over 13 synthetic steps from commercially available materials. The route employs a novel silyl ether-based strategy for accessing the 6:5:6:6 ring system of the hapalindoles rapidly and in good yields.
SYNTHETIC STUDIES OF MARINE ALKALOIDS HAPALINDOLES. Part 1. TOTAL SYNTHESIS OF (+/-)-HAPALINDOLES J and M
Muratake, Hideaki,Natsume, Mitsutaka
, p. 6331 - 6342 (2007/10/02)
The first concise synthesis of marine indole alkaloids (+/-) hapalindoles J (4) and M (5) was achieved in seven or six steps starting from a readily available compound 6 using important key reactions, 6 -> 7 -> 8 and 35 -> 41 or 5.
Synthetic studies of marine alkaloids hapalindoles. Part 3. Total synthesis of (±)-hapalindoles H and U
Muratake, Hideaki,Kumagami, Harumi,Natsume, Mitsutaka
, p. 6351 - 6360 (2007/10/02)
A total, synthesis of marine indole alkaloids (±) -hapalindoles H (1) and U (2) was achieved from the previously described compound 7 by way of 13, 21, and 26 for U (2), and 33 and 32 for H (1).
