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106940-10-7

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106940-10-7 Usage

Description

3-Pyridinemethanamine 1-oxide, also known as Nicotinamide N-oxide, is an organic compound with the molecular formula C6H7NO2. It is the N-oxide derivative of nicotinamide, a form of vitamin B3. This colorless solid is soluble in water, ethanol, and other organic solvents, and serves as a versatile chemical intermediate in various industries, including pharmaceuticals and agrochemicals. Its antioxidant and anti-inflammatory properties are currently under investigation for potential medical applications, while its skin-conditioning and brightening effects are utilized in the cosmetic sector.

Uses

Used in Pharmaceutical Industry:
3-Pyridinemethanamine 1-oxide is used as a chemical intermediate for the synthesis of various pharmaceuticals, leveraging its versatile chemical properties to facilitate the production of different medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Pyridinemethanamine 1-oxide serves as a key intermediate in the development of agrochemicals, contributing to the creation of products that enhance crop protection and yield.
Used in Cosmetics and Skin Care:
3-Pyridinemethanamine 1-oxide is utilized as a skin-conditioning agent in cosmetic and skin care products, providing benefits such as skin brightening and conditioning, enhancing the overall quality and appearance of the skin.
Used in Antioxidant and Anti-Inflammatory Research:
3-Pyridinemethanamine 1-oxide is being studied for its antioxidant and anti-inflammatory properties, with potential applications in medical research and development, particularly for conditions that could benefit from these effects.

Check Digit Verification of cas no

The CAS Registry Mumber 106940-10-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,9,4 and 0 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 106940-10:
(8*1)+(7*0)+(6*6)+(5*9)+(4*4)+(3*0)+(2*1)+(1*0)=107
107 % 10 = 7
So 106940-10-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2O/c7-4-6-2-1-3-8(9)5-6/h1-3,5H,4,7H2

106940-10-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Pyridinemethanamine 1-oxide

1.2 Other means of identification

Product number -
Other names hydrochloride salt of N-oxide-pyridin-3-yl-methylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:106940-10-7 SDS

106940-10-7Relevant articles and documents

Catalyst-free and selective oxidation of pyridine derivatives and tertiary amines to corresponding N-oxides with 1,2-diphenyl-1,1,2,2-tetrahydroperoxyethane

Azarifar, Davood,Mahmoudi, Boshra

, p. 645 - 651 (2016)

The catalyst-free oxidation of various pyridine derivatives and tertiary amines to their corresponding N-oxides with 1,1,2,2-tetrahydroperoxy-1,2-diphenylethane as an efficient oxidant has been developed. The methodology proved to tolerate a number of functional groups. The reactions proceeded smoothly under solvent-free and mild conditions at room temperature. All the products were easily extracted from the reaction mixtures in excellent yields. Graphical abstract: The catalyst-free oxidation of various pyridine derivatives and tertiary amines to their corresponding N-oxides with 1,1,2,2-tetrahydroperoxy-1,2-diphenylethane as an efficient oxidant has been developed. The methodology proved to tolerate a number of functional groups. The reactions proceeded smoothly under solvent-free and mild conditions at room temperature. All the products were easily extracted from the reaction mixtures in excellent yields.

De novo design approaches targeting an envelope protein pocket to identify small molecules against dengue virus

Acosta Dávila, John Alejandro,Adler, Natalia S.,Aucar, Maria G.,Battini, Leandro,Bollini, Mariela,Cavasotto, Claudio N.,Cordo, Sandra M.,Fernández, Gabriela A.,Gamarnik, Andrea V.,García, Cybele C.,Gebhard, Leopoldo G.,Hernández de los Ríos, Alejandro,Leal, Emilse S.,Monge, María Eugenia,Morell, María L.,Videla, Mariela

, (2019/08/30)

Dengue fever is a mosquito-borne viral disease that has become a major public health concern worldwide. This disease presents with a wide range of clinical manifestations, from a mild cold-like illness to the more serious hemorrhagic dengue fever and dengue shock syndrome. Currently, neither an approved drug nor an effective vaccine for the treatment are available to fight the disease. The envelope protein (E) is a major component of the virion surface. This protein plays a key role during the viral entry process, constituting an attractive target for the development of antiviral drugs. The crystal structure of the E protein reveals the existence of a hydrophobic pocket occupied by the detergent n-octyl-β-d-glucoside (β-OG). This pocket lies at the hinge region between domains I and II and is important for the low pH-triggered conformational rearrangement required for the fusion of the virion with the host's cell. Aiming at the design of novel molecules which bind to E and act as virus entry inhibitors, we undertook a de novo design approach by “growing” molecules inside the hydrophobic site (β-OG). From more than 240000 small-molecules generated, the 2,4 pyrimidine scaffold was selected as the best candidate, from which one synthesized compound displayed micromolar activity. Molecular dynamics-based optimization was performed on this hit, and thirty derivatives were designed in silico, synthesized and evaluated on their capacity to inhibit dengue virus entry into the host cell. Four compounds were found to be potent antiviral compounds in the low-micromolar range. The assessment of drug-like physicochemical and in vitro pharmacokinetic properties revealed that compounds 3e and 3h presented acceptable solubility values and were stable in mouse plasma, simulated gastric fluid, simulated intestinal fluid, and phosphate buffered saline solution.

Pyrimidine derivatives useful as inhibitors of PKC-theta

-

Page/Page column 128, (2008/06/13)

Disclosed are novel compounds of formula (I): wherein X, Y, R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

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