106942-35-2Relevant articles and documents
IMIDAZO[1,2-B]PYRIDAZINE IL-17A INHIBITORS
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Page/Page column 16; 36, (2020/07/25)
The invention provides certain difluorocyclohexyl-imidazopyridazinyl-imidazolidinone compounds of formula II as IL-17A inhibitors, pharmaceutical compositions thereof, and methods of using a compound of formula II to treat certain symptoms of psoriasis, rheumatoid arthritis or multiple sclerosis.
Efficient synthesis of (R)-3-amino-1,1,1-trifluoropropan-2-ol via a Dakin-West reaction followed by enantioselective reduction
Wei, Lulin,Makowski, Teresa,Martinez, Carlos,Ghosh, Arun
body text, p. 2648 - 2651 (2009/04/07)
An efficient, chromatography-free asymmetric synthesis of (R)-3-amino-1,1,1-trifluoropropan-2-ol was developed for large scale production of a cholesterol ester transfer protein (CETP) inhibitor. The synthesis features a new efficient route to a β-amino trifluoromethylketone involving a modified Dakin-West reaction followed by an asymmetric hydrogenation or an enzymatic reduction of the resulting ketone to the alcohol.