725-39-3Relevant articles and documents
IMIDAZO[1,2-B]PYRIDAZINE IL-17A INHIBITORS
-
Page/Page column 16; 36-37, (2020/07/25)
The invention provides certain difluorocyclohexyl-imidazopyridazinyl-imidazolidinone compounds of formula II as IL-17A inhibitors, pharmaceutical compositions thereof, and methods of using a compound of formula II to treat certain symptoms of psoriasis, rheumatoid arthritis or multiple sclerosis.
Reaction of (Trifluoromethyl)trimethylsilane with Oxazolidin-5-ones: Synthesis of Peptidic and Nonpeptidic Trifluoromethyl Ketones
Walter, Magnus W.,Adlington, Robert M.,Baldwin, Jack E.,Schofield, Christopher J.
, p. 5179 - 5192 (2007/10/03)
(Trifluoromethyl)trimethylsilane (TMS-CF3, the Ruppert Reagent) reacts with a variety of amino acid derived N-substituted oxazolidin-5-ones in excellent yields. Mild acid hydrolysis of adducts with electron-releasing substituents at C-2 affords