725-39-3

Upstream product

• 106942-35-2 2-phenyl-4-(2,2,2-trifluoroacetyl)-4H-oxazol-5-one 
• 1199-01-5 2-phenylazlactone 
• 495-69-2 Hippuric Acid 
• 191980-66-2 (RS)-N-benzoyl-2-(4'-methoxyphenyl)-1,3-oxazolidin-5-one 
• 1026885-87-9 [5-Hydroxy-2-(4-methoxy-phenyl)-5-trifluoromethyl-oxazolidin-3-yl]-phenyl-methanone 

Downstream Products

• 451-39-8 3-benzoylamino-2-benzoyloxy-1,1,1-trifluoro-propane 
• 33469-36-2 2-phenyl-5-(trifluoromethyl)-1H-imidazole 
• 63875-08-1 5-trifluoromethyl-1-methyl-2-phenyl-1H-imidazole 
• 727-05-9 β-Benzamido-α-hydroxy-α-trifluormethyl-propionitril 

Relevant academic research and scientific papers

IMIDAZO[1,2-B]PYRIDAZINE IL-17A INHIBITORS

The invention provides certain difluorocyclohexyl-imidazopyridazinyl-imidazolidinone compounds of formula II as IL-17A inhibitors, pharmaceutical compositions thereof, and methods of using a compound of formula II to treat certain symptoms of psoriasis, rheumatoid arthritis or multiple sclerosis.

4-trifluoroacetyl-2-phenyloxazol-5-one: Versatile template for syntheses of trifluoromethylsubstituted heterocycles

4-Trifluoroacetyl-2-phenyloxazol-5-one (1) is a versatile template for the synthesis of various trifluoromethyl-substituted heterocycles. Cyclocondesation of 1 with hydroxylamine and hydrazine afforded isoxazole and pyrazole, respectively. Another key protocol involves nucleophilic ring opening of 1 with H2O or MeOH to give a-amido trifluoromethyl ketones which are transformed into trifluoromethyl-substituted thiazoles, oxazoles, imidazoles, pyrazoles, and pyrimidines.

Reaction of (Trifluoromethyl)trimethylsilane with Oxazolidin-5-ones: Synthesis of Peptidic and Nonpeptidic Trifluoromethyl Ketones

(Trifluoromethyl)trimethylsilane (TMS-CF3, the Ruppert Reagent) reacts with a variety of amino acid derived N-substituted oxazolidin-5-ones in excellent yields. Mild acid hydrolysis of adducts with electron-releasing substituents at C-2 affords

SYNTHESIS OF FLUORINATED α-AMINO KETONES PART I: α-BENZAMIDOALKYL MONO- DI- AND TRIFLUOROMETHYL KETONES

2-Phenyl-5(4H)-oxazolones, obtained from α-amino acids, are reacted with di- and trifluoro acetic anhydride by a modified Dakin-West procedure to yield in a one-pot reaction α-benzamidoalkyl-di- and trifluoromethyl ketones in good yields.The monofluoromethyl analogues were also prepared from α-amino acids, however the use of the highly toxic fluoroacetic anhydride was avoided.The key step is the halogen exchange reaction on the corresponding bromomethyl ketone.