106944-37-0Relevant articles and documents
Substituted thiophene derivative and plant disease control agent comprising the same as active ingredient
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, (2008/06/13)
A novel substituted thiophene derivatives represented by the formula (1) in the invention: STR1 wherein R is a straight or branched alkyl group having 3-12 carbon atoms, straight or branched halogenoalkyl group having 3-12 carbon atoms, straight or branched alkenyl group having 3-10 carbon atoms, straight or branched halogenoalkenyl group having 3-10 carbon atoms, or cycloalkyl group having 3-10 carbon atoms, the cycloalkyl group being unsubstituted or substituted with an alkyl group having 1-4 carbon atoms, R and --NHCOAr are adjacent to each other, and Ar is a heterocyclic group; have excellent control activity on various plant disease such as Gray mold, Powdery mildew, Blast and Rust, and are useful as a plant disease control agent due to outstanding residual effect on Botrytis cinerea and excellent effect on Gibberella zeae.
Etude des proprietes enaminiques de l'amino-3 thiophene et du diamino-3,4 thiophene
Outurquin, Francis,Lerouge, Patrice,Paulmier, Claude
, p. 267 - 275 (2007/10/02)
In the preceding paper, access to secondary and tertiary amines derived from 3-aminothiophene 1a and 3,4-diaminothiophene 3a has been discussed (1).Our results concerning the enamine character of these thiophenic amines are presented here.Using acidic catalysis, α-deuteration of the amines 1a to 1d and α,α'-dideuteration of diamine 3a have been observed.The C-protonation of 1a explains the formation of the bis(thienyl-3)amine 5 through a transamination reaction.Bromination leads to the bromoamines 7a and 9a and α-phenylselenenylation to the phenylselenoamines 7b and 9b.The reactivity of ethyl oxomalonate toward the enamine carbons of 1a and 3a has been shown by the isolation of the aminohydroxydiesters 12 and 14.The adducts 16 and 17 have been observed in the reaction between amines 1 and ethyl pyruvate. 6-methyl 5-oxo 5H-thienopyrazine 19 is the result of the same reaction with the diamine 3a.The reductive acid-catalyzed C-alkylation of 1a and 3a, by means of an aldehyde or a ketone and two equivalents of selenophenol, allows access to 2-alkyl 3-aminothiophenes 22 and 2,5-dialkyl 3,4-diaminothiophenes 24 or to acetamides 23 and 25.