106945-36-2

Basic information

• Product Name: 2-{(S)-4-[2-(4-Chloro-phenyl)-2-hydroxy-acetylamino]-3-oxo-isoxazolidin-2-yl}-5-oxo-tetrahydro-furan-2-carboxylic acid benzhydryl ester
• CAS NO: 106945-36-2
• Molecular Weight: 564.979
• Mol File: 106945-36-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{(S)-4-[2-(4-Chloro-phenyl)-2-hydroxy-acetylamino]-3-oxo-isoxazolidin-2-yl}-5-oxo-tetrahydro-furan-2-carboxylic acid benzhydryl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{(S)-4-[2-(4-Chloro-phenyl)-2-hydroxy-acetylamino]-3-oxo-isoxazolidin-2-yl}-5-oxo-tetrahydro-furan-2-carboxylic acid benzhydryl ester(106945-36-2)
• EPA Substance Registry System: 2-{(S)-4-[2-(4-Chloro-phenyl)-2-hydroxy-acetylamino]-3-oxo-isoxazolidin-2-yl}-5-oxo-tetrahydro-furan-2-carboxylic acid benzhydryl ester(106945-36-2)

Safety Data

• Hazardous Substances Data: 106945-36-2(Hazardous Substances Data)

Upstream product

• 7138-34-3 p-chloromandelic acid 
• 106962-17-8 benzhydryl 2-<(4S)-4-amino-3-oxo-2-isoxazolidinyl>-5-oxo-2-tetrahydrofurancarboxylate 

Downstream Products

• 106963-36-4 Na salt of N-(p-chloro-mandelyl)-4-amino-lactivinic acid 

Relevant articles and documents

CHEMISTRY OF A NEW ANTIBIOTIC: LACTIVICIN

A novel antibiotic, lactivicin (LTV), was isolated from the culture filtrates of two bacterial strains by various types of chromatography.LTV exists in aqueous solution as an equilibrium mixture of two epimers in a ratio of about 1:1.The chemical structure of LTV (C10H12N2O7) was determined to be 2-(4S-acetylamino-3-oxo-2-isoxazolidinyl)-5-oxo-tetrahydrofuran-2-carboxylic acid.The absolute configuration at the C-6 position was elucidated from the CD spectral data and X-ray crystallographic analysis of 4-amino-lactivinic acid obtained by the iminoether method.This compound is useful as a starting material for chemical modification.LTV showed antibacterial activity against Gram-positive and negative bacteria, susceptibility to β-lactamases, and affinity for penicillin-binding proteins.We therefore concluded that LTV is a novel skeleton antibiotic having β-lactam-like activities.