106988-43-6

Basic information

• Product Name: 9-aminoacridine-4-carboxamide
• Synonyms: 9-aminoacridine-4-carboxamide;4-Acridinecarboxamide, 9-amino-;9-Aa-4-ca
• CAS NO: 106988-43-6
• Molecular Formula: C14H11 N3 O
• Molecular Weight: 0
• Mol File: 106988-43-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 576.8°Cat760mmHg
• Flash Point: 302.6°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 2.64E-13mmHg at 25°C
• Refractive Index: 1.795
• CAS DataBase Reference: 9-aminoacridine-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 9-aminoacridine-4-carboxamide(106988-43-6)
• EPA Substance Registry System: 9-aminoacridine-4-carboxamide(106988-43-6)

Safety Data

• Hazardous Substances Data: 106988-43-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H11N3O/c15-12-8-4-1-2-7-11(8)17-13-9(12)5-3-6-10(13)14(16)18/h1-7H,(H2,15,17)(H2,16,18)

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Groove selectivity in the interaction of 9-aminoacridine-4-carboxamide (cas 106988-43-6) antitumor agents with DNA08/12/2019

Theoretical quantitative evaluation of the intercalative binding to DNA of the new antitumor drug 9-amino-acridine-4-carboxamide indicates that, in contradiction with a recently proposed model, the compound should show specificity for interaction with the major (and not minor) groove of GC seque...detailed

The interaction of DNA-targeted 9-aminoacridine-4-carboxamide (cas 106988-43-6) platinum complexes with DNA in intact human cells08/11/2019

As part of an ongoing drug development programme, this paper describes the sequence specificity and time course of DNA adduct formation for a series of novel DNA-targeted analogues of cis-diaminedichloroplatinum(II) (cisplatin) (9-aminoacridine-4-carboxamide Pt complexes) in intact HeLa cells. T...detailed

Synthesis and biological evaluation of new 9-aminoacridine-4-carboxamide (cas 106988-43-6) derivatives as anticancer agents08/07/2019

The design of molecules that recognize the specific sequence of the DNA double helix or those that can stabilize DNA topoisomerase cleavable complex to stop the progression of DNA process, may be very useful in cancer chemotherapy. In the field of antituor DNA-intercalating agents, 9-aminoacridi...detailed