107002-91-5Relevant academic research and scientific papers
Erythro-Directive Reduction of α-Substituted Alkanones by Means of Hydrosilanes in Acidic Media
Fujita, Makoto,Hiyama, Tamejiro
, p. 5415 - 5421 (2007/10/02)
Hydrosilane reduced α-oxy and α-amino ketones and β-keto acid derivatives in trifluoroacetic acid to afford the corresponding erythro alcohols with high diastereoselectivity.The reaction proceeded without racemization at the carbon α to the carbonyl group.The erythro-directive reduction was explained in terms of the proton-bridged Cram cyclic model and successfully applied to the synthesis of physiologically important amino alcohols such as l-ephedrine, l-methoxamine, and erythro-2-methyl-3-piperidino-1-phenylpropanol.
REDUCTION OF OXIMES WITH HYDROSILANE/H(1+) REAGENT
Fujita, Makoto,Oishi, Haruhito,Hiyama, Tamejiro
, p. 837 - 838 (2007/10/02)
Hydrosilane/H+ reagent reduced oximes in good yields.Stereospecific reduction of (2-acetoxy-1-phenylpropylidene) benzyloxyazane (3) was observed; the (E)-isomer gave erythro-1-phenyl-1-benzyloxyamino-2-propanol (4) in 99percent selectivity, whe
