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107007-95-4

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107007-95-4 Usage

Uses

Granisetron Impurity B having 5-HT antagonist activity.

Check Digit Verification of cas no

The CAS Registry Mumber 107007-95-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,0,0 and 7 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 107007-95:
(8*1)+(7*0)+(6*7)+(5*0)+(4*0)+(3*7)+(2*9)+(1*5)=94
94 % 10 = 4
So 107007-95-4 is a valid CAS Registry Number.

107007-95-4 Well-known Company Product Price

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  • Sigma-Aldrich

  • (Y0000478)  Granisetron impurity B  European Pharmacopoeia (EP) Reference Standard

  • 107007-95-4

  • Y0000478

  • 1,880.19CNY

  • Detail
  • USP

  • (1298128)  Granisetron Related Compound B  United States Pharmacopeia (USP) Reference Standard

  • 107007-95-4

  • 1298128-15MG

  • 13,747.50CNY

  • Detail

107007-95-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide

1.2 Other means of identification

Product number -
Other names M-1285

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:107007-95-4 SDS

107007-95-4Downstream Products

107007-95-4Relevant articles and documents

Synthesis and Pharmacological Evaluation of [11C]Granisetron and [18F]Fluoropalonosetron as PET Probes for 5-HT3 Receptor Imaging

Mu, Linjing,Müller Herde, Adrienne,Rüefli, Pascal M.,Sladojevich, Filippo,Milicevic Sephton, Selena,Kr?mer, Stefanie D.,Thompson, Andrew J.,Schibli, Roger,Ametamey, Simon M.,Lochner, Martin

, p. 1552 - 1564 (2016)

Serotonin-gated ionotropic 5-HT3 receptors are the major pharmacological targets for antiemetic compounds. Furthermore, they have become a focus for the treatment of irritable bowel syndrome (IBS) and there is some evidence that pharmacological modulation of 5-HT3 receptors might alleviate symptoms of other neurological disorders. Highly selective, high-affinity antagonists, such as granisetron (Kytril) and palonosetron (Aloxi), belong to a family of drugs (the "setrons") that are well established for clinical use. To enable us to better understand the actions of these drugs in vivo, we report the synthesis of 8-fluoropalonosetron (15) that has a binding affinity (Ki = 0.26 ± 0.05 nM) similar to the parent drug (Ki = 0.21 ± 0.03 nM). We radiolabeled 15 by nucleophilic 18F-fluorination of an unsymmetrical diaryliodonium palonosetron precursor and achieved the radiosynthesis of 1-(methyl-11C)-N-granisetron ([11C]2) through N-alkylation with [11C]CH3I, respectively. Both compounds [18F]15 (chemical and radiochemical purity >95%, specific activity 41 GBq/μmol) and [11C]2 (chemical and radiochemical purity ≥99%, specific activity 170 GBq/μmol) were evaluated for their utility as positron emission tomography (PET) probes. Using mouse and rat brain slices, in vitro autoradiography with both [18F]15 and [11C]2 revealed a heterogeneous and displaceable binding in cortical and hippocampal regions that are known to express 5-HT3 receptors at significant levels. Subsequent PET experiments suggested that [18F]15 and [11C]2 are of limited utility for the PET imaging of brain 5-HT3 receptors in vivo.

Toward biophysical probes for the 5-HT3 receptor: Structure-activity relationship study of granisetron derivatives

Vernekar, Sanjeev Kumar V.,Hallaq, Hasan Y.,Clarkson, Guy,Thompson, Andrew J.,Silvestr, Linda,Lummis, Sarah C. R.,Lochner, Martin

supporting information; experimental part, p. 2324 - 2328 (2010/07/17)

This report describes the synthesis and biological characterization of novel granisetron derivatives that are antagonists of the human serotonin (5-HT3A) receptor. Some of these substituted granisetron derivatives showed low nanomolar binding affinity and allowed the identification of positions on the granisetron core that might be used as attachment points for biophysical tags. A BODIPY fluorophore was appended to one such position and specifically bound to 5-HT3A receptors in mammalian cells.

Indazolyl carboxylic acid amides useful for treating migraine clusters headache, trigeminal neuralgia or emesis

-

, (2008/06/13)

Compounds of formula (I) and pharmaceutically acceptable salts thereof: STR1 wherein X is CO and Y is NH; Z is NR3 wherein R3 is hydrogen, C1-6 alkyl, C3-7 alkenyl-methyl, phenyl or phenyl C1-4 alkyl either of which phenyl moieties may be substituted by one or two of halogen, CF3, C1-6 alkoxy or C1-6 alkyl; and Ra is not present; or Z is N and Ra is as defined for R3 above; Rb is present when X-Y-R2 is attached at the phenyl ring and is selected from hydrogen, halogen, CF3, hydroxy, C1-6 alkoxy or C1-6 alkyl; R1 is hydrogen, halogen, CF3, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-7 acyl, C1-7 acylamino, C1-6 alkylsulphonylamino, N(C1-6 alkylsulphonyl)-N-C1-4 alkylamino, C1-6 alkylsulphinyl, hydroxy, nitro or amino, aminocarbonyl, aminosulphonyl, aminosulphonylamino or N-(aminosulphonyl)-C1-4 alkylamino optionally N-substituted by one or two groups selected from C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl C1-4 alkyl, phenyl or phenyl C1-4 alkyl groups or optionally N-disubstituted by C4-5 polymethylene; R2 is a group of formula (a) STR2 wherein n is 2 or 3; and R4 is C1-7 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl-C1-2 alkyl, or a group (CH2)t R6 where t is 1 or 2 and R6 is thienyl, pyrrolyl or furyl optionally substituted by one or two substituents selected from C1-6 alkyl, C1-6 alkoxy, trifluoromethyl or halogen, or is phenyl optionally substituted by one or two substituents having 5-HT antagonist activity and/or gastric motility enhancing activity.

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