1070436-97-3

Upstream product

• 36404-88-3 2-chloro-3-carbaldehydepyridine 
• 2746-25-0 p-Methoxybenzyl bromide 
• 271-73-8 1H-Pyrazolo[3,4-b]pyridine 
• 824-94-2 p-methoxybenzyl chloride 
• 117007-52-0 3-iodo-1H-pyrazolo[3,4-b]pyridine 

Downstream Products

• 1070436-99-5 (E)-3-[1-(4-methoxy-benzyl)-1H-pyrazolo[3,4-b] pyridin-3-yl]-acrylic acid ethyl ester 
• 1246521-00-5 C₂₀H₂₃N₃O₃ 
• 1246520-84-2 C₁₉H₁₉N₃O₃ 
• 1246520-73-9 C₁₉H₁₉N₃O₃ 
• 1137734-93-0 C₁₈H₁₅N₃O₃ 
• 1246520-74-0 C₁₇H₁₅N₃O₃ 
• 1246519-54-9 C₁₈H₁₈N₄O₂ 
• 1246519-62-9 C₁₇H₁₇ClN₄O 
• 1246519-71-0 C₁₉H₂₂N₄O 
• 1246519-76-5 C₁₈H₂₀N₄O₂ 
• 1246519-78-7 C₂₂H₂₇N₅O₃ 
• 1246519-79-8 C₂₃H₂₉N₅O₃ 
• 1246520-07-9 C₁₈H₁₉ClN₄O 
• 1246520-09-1 C₂₀H₂₃ClN₄O 

Relevant academic research and scientific papers

Palladium-catalyzed aminocarbonylation of halo-substituted 7-azaindoles and other heteroarenes using chloroform as a carbon monoxide source

A palladium-catalyzed aminocarbonylation of halo-substituted 7-azaindoles utilizing CHCl3 as the carbonyl source has been developed for the straightforward incorporation of an amide functional group. The protocol was extended to other heteroarenes such as pyrazolopyridines and indazoles. The substrate scope of the reaction with respect to heteroarenes and the amine component is reported. This method offers an alternative avenue for aminocarbonylation of pharmaceutically important heterocycles.

BICYCLIC HETEROARYL INDOLE ANALOGUES USEFUL AS ROR GAMMA MODULATORS

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X, X1, M, R2, R3, R4, R5, m, n, and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, neurodegenerative diseases and cancer.

INDAZOLEPROPIONIC ACID AMIDE COMPOUND

Disclosed is a compound which is useful in preventing and treating cardiac arrhythmia such as atrial fibrillation. A compound represented by formula (1) or a pharmaceutically acceptable salt of the same. In formula (1), ring X represents benzene or pyridine; R1 represents an optionally substituted alkyl group; R2 represents an optionally substituted aryl group, an optionally substituted heterocyclic group, an optionally substituted arylalkyl group or an optionally substituted heterocyclic group-substituted alkyl group; R3, R4, R5, R6, R7, R8 and R9 represent each hydrogen or an alkyl group, provided that R3 and R5 may be bonded to each other to form, together with the carbon atom adjacent thereto, a cycloalkyl group; and m represents 0 or 1.

Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors

Substituted 1H-pyrazolo[3,4-b]pyridine-3-yl-acrylamide compounds of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer