36404-88-3

Basic information

• Product Name: 2-Chloro-3-pyridinecarboxaldehyde
• Synonyms: CHLORO-2-FORMYL-3-PYRIDINE;2-CHLORO-PYRIDINE-3-CARBALDEHYDE;2-CHLOROPYRIDINE-3-CARBOXALDEHYDE;2-CHLORO-PYRIDIN-3-CARBALDEHYDE;2-CHLORONICOTINALDEHYDE;2-CHLORO-3-FORMYLPYRIDINE;2-CHLORO-3-PYRIDINECARBOXALDEHYDE;TIMTEC-BB SBB004156
• CAS NO: 36404-88-3
• Molecular Formula: C₆H₄ClNO
• Molecular Weight: 141.56
• Product Categories: Pyridine;pharmacetical;Pyridines;Aldehyde;Building Blocks;CHIRAL CHEMICALS;Chlorinated heterocyclic series;Aromatics;Heterocycles;Miscellaneous Reagents;Aldehydes;C1 to C6;C5 to C6;C6 to C7;Carbonyl Compounds;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Organic Building Blocks;Heterocycle-Pyridine series;aldehyde| alkyl chloride
• Mol File: 36404-88-3.mol
• Article Data: 34

Chemical Properties

• Melting Point: 50-54 °C(lit.)
• Boiling Point: 242.264 °C at 760 mmHg
• Flash Point: >230 °C
• Appearance: White to off-white/Powder or Low Melting Solid
• Density: 1.332 g/cm³
• Vapor Pressure: 0.034mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Room temperature.
• Solubility: Chloroform, DMSO
• PKA: -1.36±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-3-pyridinecarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-pyridinecarboxaldehyde(36404-88-3)
• EPA Substance Registry System: 2-Chloro-3-pyridinecarboxaldehyde(36404-88-3)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 36404-88-3(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Uses

Different sources of media describe the Uses of 36404-88-3 differently. You can refer to the following data:
1. Starting material for the preparation of 5-azaindoles by the Hemetsberger-Knittel reaction involving the thermal decomposition of alkenyl azides.1
2. Azaindazole intermediate.
3. Starting material for the preparation of 5-azaindoles by the Hemetsberger-Knittel reaction involving the thermal decomposition of alkenyl azides.

InChI:InChI=1/C6H4ClNO/c7-6-5(4-9)2-1-3-8-6/h1-4H

Upstream product

• 109-09-1 2-chloropyridine 
• 109-94-4 formic acid ethyl ester 
• 73583-37-6 2-chloro-4-bromopyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 2591-86-8 N-Formylpiperidine 
• 591-50-4 iodobenzene 
• 1640100-22-6 (2-chloropyridin-3-yl)methyl acetate 
• 18368-76-8 2 chloro-3-methylpyridine 
• 89581-84-0 2-chloro-3-(chloromethyl)pyridine 
• 108-18-9 diisopropylamine 
• 7226-23-5 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone 
• 52200-48-3 3-bromo-2-chloropyridine 
• 49609-84-9 2-Chloronicotinoyl chloride 
• 2942-59-8 2-chloronicotinic acid 

Downstream Products

• 111079-40-4 2-phenylthieno<2,3-b>pyridine 
• 1259948-65-6 (E)-3-[2-(2-bromophenyl)-2-fluorovinyl]-2-chloropyridine 
• 35567-32-9 2-(dimethylamino)pyridine-3-carbaldehyde 
• 59944-76-2 thieno[2,3-b]pyridine-2-carboxylic acid 
• 688357-19-9 4-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid methyl ester 
• 868526-52-7 1-(2-pentyloxypyridin-3-yl)-but-3-yn-1-ol 
• 852063-33-3 ethyl 4-oxo-4-(2-(benzylseleno)pyridin-3-yl)butyrate 
• 852063-32-2 ethyl 4-(2-chloropyridin-3-yl)-4-oxobutyrate 
• 120739-88-0 (2-chloro-pyridin-3-ylmethyl)-methyl-amine 
• 494841-80-4 2-chloro-3-{(E)-[2-(4S,5S)-4-methoxymethyl-5-(4-methylthiophenyl)-4,5-dihydro-1,3-oxazol-2-yl]vinyl}pyridine 
• 116854-97-8 2-hydrazinopyridine-3-aldehyde azine 
• 271-73-8 1H-Pyrazolo[3,4-b]pyridine 
• 61856-52-8 3-formyl-pyridine-2(1H)-thione 
• 142274-26-8 (3-formyl-pyridin-2-ylsulphanyl)-propionic acid methyl ester 

Relevant articles and documents

Synthesis of a 1,8-napththyridin-5-one derivative via an intramolecular 1,3-dipolar cycloaddition reaction

Synthesis of a 1,8-naphthyridin-5-one derivative [(5,6,7,8-tetrahydro-(3-chloro-6-hydroxymethyl-8-methyl)-1,8-naphthyri din-5-one (9)] is described starting from 2-chloronicotinic acid using an intramolecular 1,3-dipolar cycloaddition reaction as the key step.

FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS

Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I).

PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS

Compounds of the general formula(I): (I) processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.